CHU de Nice
Nice, 06000, France
NCT Number: NCT02830620
The syndrome of anorexia-cachexie, which accompanies numerous cancers is a major comorbidity which compromises the forecast of these patients. Several cytokines pro-inflammatory as interleukines IL1 ß, IL6 or TNFa participate in the physiopathology of this syndrome at the man and the animal. Besides, it is now established that different neuronal populations, localized in the hypothalamus, are nerve centers of the control of the appetite and the energy homéostasie. However, there is not enough evidence of a direct action of cytokines on these neurones, suggesting the participation of intermediate molecules as chimiokines, inflammatory molecules produced in reaction to an immunological stress by gliales cells and acting directly on the surrounding neurones. The implication of chimiokines in the syndrome of anorexia-cachexie associated with the cancer thus seems very likely Among these, chimiokines " Monocyte Chemoattractant Proteins 1-3 " or MCPs represent obvious candidates because they are produced by multiple tumors. Furthermore, to the mouse, the intellectual expression of MCP1 is correlated in the anorexia led by peripheral injections of a bacterial by-product, the lipopolysaccharide (LPS).
The investigators' main objective is to test at the Man's, in situation of cancer of the pancreas any confused stages, the degree of prédictivité of the chimiokine MCP1 towards the syndrome of anorexia-cachexie associated with the cancer. The investigator also suggest describing: i) the link between rate plasmatique of MCP1 and energy metabolism on one hand, physical composition on the other hand;; ii) the impact of the other chimiokines, particularly those of the family of the MCPs, on the anorexia-cachexie bound to the cancer, iii) the correlation enters their profile of expression plasmatique and the severity of the anorexia, the energy metabolism and the physical composition; iv) the same research on the other inflammatory factors plasmatiques, of nature different from chimiokines; v) the correlation between thin mass and anorexia; vi) the evolution of the chimiokines various and inflammatory factors after surgical treatment or chemotherapy with curative aim in 6 months.
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Notify Me18 year and older
All sexes
Interventional
Not applicable
Nice, 06000, France
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Group 1 {cancer of the pancreas WITH syndrome of anorexia-cachexie}
Inclusion criteria
Exclusion criteria
Groupe 2 {cancer du pancréas SANS syndrome d'anorexie-cachexie}
Inclusion criteria
Exclusion criteria
Group 3 {pure food limitation typifies restrictive anorexia nervosa}
Inclusion criteria
Exclusion criteria
Group 4 {unhurt individual of any appetite-suppressing evolutionary disease and cachectisante}
Inclusion criteria
Exclusion criteria
Time frame: change from baseline to 180 days
Study at the Man's, in situation of cancer of the pancreas, diagnosed of novo and any confused stages, the prediction of the chimiokine MCP1 towards the syndrome of anorexia-cachexie associated with the cancer
Centre Hospitalier Universitaire de Nice
Other
Study at the Man of the Profile of Chimiokines in the Anorexia Bound to the Cancerous Cachexy.
Acronym: CHIMIOKINES
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