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OpenTrials
Completed

NCT Number: NCT00587106

Studies of Neurological Paraneoplastic Syndromes

This study is for patients with cancer, a known paraneoplastic syndrome, or neurological problems that suggest a paraneoplastic syndrome.

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Key information

Conditions

Paraneoplastic Neurologic Degenerations (PNDs)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Memorial Sloan Kettering Cancer Center

New York, 10065, United States

About this study

Patients usually go to their doctors with neurological complaints and later find they have cancer, a known paraneoplastic syndrome, or neurological problems that suggest a paraneoplastic syndrome. Paraneoplastic syndromes are rare conditions in which the immune system is involved in causing brain damage and fighting cancer.

Such patients with paraneoplastic neurologic degenerations(PNDs) may have autoantibodies, an antibody or protein the immune system creates that is directed against his or her own proteins. This study aims to better understand PNDS by:

  • analyzing for autoantibodies in serum and cerebral spinal fluid
  • analyzing for antigen specificity and for antigens in cancer tissue
  • comparing PND autoantibodies with those in cancer patients but no PND
  • comparing PND autoantibodies with those in PND patients but no cancer
  • studying the immune performance of patients with PNDs

As this study is not a treatment study, tissues for this study will only come from procedures necessary for the patient's treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All adults are potentially eligible.

Exclusion criteria

  • None.

Treatment and study plan

Primary outcomes

  1. Increase understanding of PNDS

    Time frame: Ongoing

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Collaborators

  • National Institutes of Health (NIH)

Registry information

Important dates

Study start
1988
Primary completion
2009
Study completion
2009
First posted
Jan 7, 2008
Registry last updated
Mar 30, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.