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NCT Number: NCT07742904

Stroke Volume Versus Inferior Vena Cava Collapsibility Index to Predict Postinduction Hypotension in Intestinal Obstruction

Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow tract velocity time integral (LVOT-VTI) versus the inferior vena cava collapsibility index (IVC-CI) using transthoracic echocardiography. The assessment will be conducted in adult patients with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia.

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Key information

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Observational

About this study

Postinduction hypotension (PIH) is associated with adverse postoperative outcomes. In this diagnostic accuracy observational study, adult patients aged 40-70 years with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia will be enrolled at Ain Shams University Hospitals. Prior to induction of general anesthesia, transthoracic echocardiography (TTE) will be performed to measure the stroke volume (SV) via LVOT-VTI and the inferior vena cava collapsibility index (IVC-CI). Patients will receive standard rapid sequence induction, and hemodynamic parameters will be monitored post-induction to evaluate the predictive value, sensitivity, and specificity of SV versus IVC-CI for postinduction hypotension. Secondary outcomes including incidence of PIH, length of hospital stay, PACU recovery time, and postoperative nausea and vomiting will also be recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients with intestinal bowel obstruction undergoing exploratory abdominal surgery under general anesthesia.
  • Age 40 to 70 years old.
  • Body Mass Index (BMI) = 18 to 25 kg/m2.
  • American Society of Anesthesiologists (ASA) physical status grade I or II.

Exclusion criteria

  • American Society of Anesthesiologists (ASA) physical status grade >= III.
  • Patients in whom the IVC cannot be visualized or patients with poor echogenicity.
  • Patients with hemodynamic instability.
  • Patients with vascular, respiratory, or cardiac diseases (e.g., cardiomyopathy, heart valve disease, arrhythmia, or bad exercise tolerance).
  • Pregnant patients.
  • Difficult airway or multiple intubatio

Treatment and study plan

Primary outcomes

  1. Efficacy of SV versus IVC-CI as Predictors for Post-Induction Hypotension Efficacy of SV versus IVC-CI as Predictors for Post-Induction Hypotension

    Time frame: Measured baseline pre-induction and compared immediately post-induction.

    Comparison of the effectiveness and diagnostic accuracy (AUC) of stroke volume (SV) measured via LVOT-VTI versus inferior vena cava collapsibility index (IVC-CI) measured via TTE in predicting post-induction hypotension.

    Comparison of the effectiveness and diagnostic accuracy (AUC) of stroke volume (SV) measured via LVOT-VTI versus inferior vena cava collapsibility index (IVC-CI) measured via TTE in predicting post-induction hypotension.

Secondary outcomes

  1. Incidence of Post-Induction Hypotension Incidence of Post-Induction Hypotension

    Time frame: Within 3 minutes following induction of general anesthesia.

    Assessment of the proportion of patients who develop post-induction hypotension, defined as SBP decrease > 30%, MAP decrease > 20% from baseline, or absolute SBP < 90 mmHg and MAP < 60 mmHg.

  2. Length of Hospital Stay Length of Hospital Stay

    Time frame: From date of surgery until hospital discharge (up to 9 months).

    Total duration of hospitalization from the day of surgery until discharge.

  3. Time to Recovery from Post-Anesthesia Care Unit (PACU) Time to Recovery from Post-Anesthesia Care Unit (PACU)

    Time frame: Intraoperative / immediate postoperative period until PACU discharge (up to 24 hours).

    Time elapsed from patient admission to the PACU until meeting discharge criteria.

    Time elapsed from patient admission to the PACU until meeting discharge criteria.

Study contacts

Contact information is provided by the study sponsor or research team.

Islam A Taher, M.D.

CONTACT

+201005629809

Noura A Kamal, M.Sc.

CONTACT

[email protected]

+201119774236

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 3, 2026
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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