Prediction of Post-Induction Hypotension Using Plethysmographic Variability Index During Diagnostic Laryngoscopy
NCT07458893
Post-Induction Hypotension
View Trial DetailsNCT Number: NCT07742904
Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow tract velocity time integral (LVOT-VTI) versus the inferior vena cava collapsibility index (IVC-CI) using transthoracic echocardiography. The assessment will be conducted in adult patients with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia.
Trial opening soon.
Get Notified40 year–70 year
All sexes
Observational
Postinduction hypotension (PIH) is associated with adverse postoperative outcomes. In this diagnostic accuracy observational study, adult patients aged 40-70 years with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia will be enrolled at Ain Shams University Hospitals. Prior to induction of general anesthesia, transthoracic echocardiography (TTE) will be performed to measure the stroke volume (SV) via LVOT-VTI and the inferior vena cava collapsibility index (IVC-CI). Patients will receive standard rapid sequence induction, and hemodynamic parameters will be monitored post-induction to evaluate the predictive value, sensitivity, and specificity of SV versus IVC-CI for postinduction hypotension. Secondary outcomes including incidence of PIH, length of hospital stay, PACU recovery time, and postoperative nausea and vomiting will also be recorded.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: Measured baseline pre-induction and compared immediately post-induction.
Comparison of the effectiveness and diagnostic accuracy (AUC) of stroke volume (SV) measured via LVOT-VTI versus inferior vena cava collapsibility index (IVC-CI) measured via TTE in predicting post-induction hypotension.
Comparison of the effectiveness and diagnostic accuracy (AUC) of stroke volume (SV) measured via LVOT-VTI versus inferior vena cava collapsibility index (IVC-CI) measured via TTE in predicting post-induction hypotension.
Time frame: Within 3 minutes following induction of general anesthesia.
Assessment of the proportion of patients who develop post-induction hypotension, defined as SBP decrease > 30%, MAP decrease > 20% from baseline, or absolute SBP < 90 mmHg and MAP < 60 mmHg.
Time frame: From date of surgery until hospital discharge (up to 9 months).
Total duration of hospitalization from the day of surgery until discharge.
Time frame: Intraoperative / immediate postoperative period until PACU discharge (up to 24 hours).
Time elapsed from patient admission to the PACU until meeting discharge criteria.
Time elapsed from patient admission to the PACU until meeting discharge criteria.
Contact information is provided by the study sponsor or research team.
Islam A Taher, M.D.
CONTACT
Noura A Kamal, M.Sc.
CONTACT
Ain Shams University
Other
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT07458893
Post-Induction Hypotension
View Trial DetailsNCT07529795
Digestive System Diseases, Infections
Hanoi, Vietnam
View Trial DetailsNCT06772727
Emergency Laparotomy, Lidocaine
Cairo, Egypt
View Trial DetailsNCT05881291
General Anesthesia, Hemodynamics
Hangzhou, Zhejiang, China
View Trial Details