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NCT Number: NCT02459470

Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation

The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.

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Key information

Conditions

Kidney Transplantation

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Samsung Seoul Hospital, Samsung Medical Center

Seoul, 135-710, South Korea

About this study

Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • chronic renal failure patients undergoing renal transplantation

Exclusion criteria

  • patients with cardiac arrhythmia
  • patients with reduced left ventricular function (EF < 40%)
  • patients with valvular heart disease
  • patients intracardiac shunt
  • patients with pulmonary hypertension
  • patients with extensive peripheral vascular disease
  • patients with preoperative use of vasopressors or inotropics

Treatment and study plan

Fluid loading

Procedure

fluid loading was performed by using 7ml/kg of 6% hydroxyethyl starch within 10 min to all patients

Other names: HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland

Primary outcomes

  1. stroke volume variation from Flo stroke volume variation from FloTrac/Vigileo system

    Time frame: within 5 minutes after fluid expansion

    predictable of stroke volume variation from FloTrac/Vigileo system for fluid responsiveness

  2. pulse pressure variation from philips Intelivue MP70 monitor

    Time frame: within 5 minutes after fluid expansion

    predictable of pulse pressure variation from philips Intelivue MP70 monitor for fluid responsiveness

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Utility of Stroke Volume Variation and Pulse Pressure Variation for Predicting Fluid Responsiveness in Chronic Renal Failure Patients Undergoing Kidney Transplantation

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Jun 2, 2015
Registry last updated
Jun 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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