Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention

Stroke-like migraine attacks after radiation therapy-also known as SMART syndrome-constitute a rare condition typically characterized by headache, seizures, vision abnormalities, hemiparesis, and aphasia. The condition usually resolves within a few days or weeks of onset with no residual impairments. However, resolution in some cases extends over a period of months rather than weeks and may be incomplete. The purpose of this case report is to provide an in-depth description of the progression of changes in cognitive and language functioning for a person exhibiting SMART syndrome characterized by slow recovery.

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Key information

Conditions

Migraine Disorders Aphasia Brain Diseases Central Nervous System Diseases Cognition Disorders Cognitive Dysfunction Communication Disorders Headache Disorders Headache Disorders, Primary Language Disorders Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Speech Disorders

Age range

19 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Quality Living, Inc.

Omaha, Nebraska, 68104, United States

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

exhibit cognitive and language deficits secondary to SMART syndrome
be a former or current client of Quality Living, Inc., Omaha, Nebraska
be a native speaker of English

Exclusion criteria

Treatment and study plan

Language Treatment

Behavioral

Individual speech-language therapy sessions totaling 1.5 to 2.5 hours five days per week. Intervention activities include performing oral and written confrontation and responsive naming, writing single words to dictation, reading single words and sentences aloud, and generating written and spoken picture descriptions.

Primary outcomes

Standardized assessment

Time frame: Change from baseline at 6 months

Aphasia Quotient of the Western Aphasia Battery - Revised

Secondary outcomes

Spoken picture description

Time frame: Change from baseline at 6 weeks, 10 weeks, 14 weeks, 20 weeks, and 26 weeks

Spoken language sample elicited through a request to describe events depicted in a Norman Rockwell drawing.
Written picture description

Time frame: Change from baseline at 6 weeks, 10 weeks, 14 weeks, 20 weeks, and 26 weeks

Written language sample elicited through a request to write about events depicted in a Norman Rockwell drawing.

Sponsors and collaborators

Lead sponsor

Quality Living, Inc.

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Sep 7, 2018
Registry last updated: Mar 10, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed