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NCT Number: NCT05252208

Stretching vs Walking for Lowering Blood Pressure

High blood pressure is a leading risk factor for cardiovascular disease. Traditionally, one of the ways to treat or prevent high blood pressure is to prescribe aerobic exercise training (i.e. brisk walking). Stretching may also be effective because it may cause changes in blood vessel stiffness and therefore reduce resistance to blood flow. The study will assess a group of individuals (i.e. 96) participating in a supervised stretching or walking program five days per week for six months to determine whether stretching is superior for reducing blood pressure. This research will contribute to recommendations about the most effective exercise programs for reducing blood pressure and risk of cardiovascular disease.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Saskatchewan

Saskatoon, Saskatchewan, S7N5B2, Canada

Location status: Recruiting

Location contact

John Ko, M.Sc.

CONTACT

[email protected]

306-966-1186

About this study

Hypertension or high blood pressure is a prevalent and leading risk factor for heart disease and stroke afflicting seven million people in Canada and costing our health system approximately $20 billion annually. The prevailing exercise recommendation for people with hypertension is to perform aerobic training (i.e. brisk walking) as a non-pharmacological way to moderately reduce blood pressure. Evidence from several recent studies indicates flexibility training may accrue more positive changes in blood pressure than aerobic training. Additional recent studies show stretching can reduce arterial stiffness and sympathetic nervous system activation, suggesting physiological mechanisms by which blood pressure might be reduced through exercises designed mostly to improve flexibility. The purpose of this study is to determine if a 6-month flexibility program is superior to aerobic training for reducing 24-hour blood pressure measurements, improving measures of vascular function (i.e. arterial stiffness), and improving the ratio of parasympathetic to sympathetic nervous system activation. This study involves a randomized controlled trial of 96 men and women presenting with either high-normal blood pressure (systolic 130 to 139 mmHg or diastolic 85 to 89 mmHg) or stage 1 hypertension (systolic 140 to 159 mmHg or diastolic 90 to 99 mmHg) stratified by blood pressure (i.e. either high normal or stage 1 hypertension), sex, and age (≥55y or <55y) and randomized to one of two groups for six months duration: 1) a flexibility program (30 minutes of stretching per day); or 2) an aerobic training program (30 minutes of brisk walking per day). Assessments pre- and post-intervention and three months later include: 24-hour ambulatory blood pressure, arterial stiffness, and heart rate variability. .

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systolic blood pressure between 130 and 159 mmHg OR diastolic blood pressure between 85 and 99 mmHg
  • Able to walk unaided for 30 minutes
  • Can safely perform exercises as determined by the Get Active Questionnaire

Exclusion criteria

  • Not on blood pressure medication unless it has been a stable dose for 6 months and target blood pressure has not been achieved (i.e. below 140/90 mmHg)
  • Smoking
  • Already performing 150 minutes or more moderate to vigorous physical activity per week
  • Already involved in a flexibility-training program (e.g. Yoga or Pilates)
  • Pregnant or lactating or planning to become pregnant during the study

Treatment and study plan

stretching exercise

Other

Stretching (30-45 minutes, 5 days per week, 6 months)

Walking Exercise

Other

Walking (30-45 minutes, 5 days per week, 6 months)

Primary outcomes

  1. Night time systolic and diastolic blood pressure

    Time frame: Change from baseline night time blood pressure at 6 months

    Blood pressure assessed during the night with an automated device

Secondary outcomes

  1. Day time systolic and diastolic blood pressure

    Time frame: Change from baseline day time blood pressure at 6 months

    Blood pressure assessed during the day with an automated device

  2. Sitting systolic and diastolic blood pressure

    Time frame: Change from baseline sitting blood pressure at 6 months

    Blood pressure assessed while sitting

  3. Lying systolic and diastolic blood pressure

    Time frame: Change from baseline lying blood pressure at 6 months

    Blood pressure assessed while lying supine

  4. Arterial stiffness

    Time frame: Change from baseline arterial stiffness at 6 months

    Arterial stiffness assessed with aplanation tonometry

  5. Heart rate variability

    Time frame: Change from baseline heart rate variability at 6 months

    Heart rate variability assessed with electrocardiography

  6. Hamstrings flexibility

    Time frame: Change from baseline hamstrings flexibiliity at 6 months

    Hamstrings flexibility assessed with a sit-and-reach test

  7. Shoulder flexibility

    Time frame: Change from baseline shoulder flexibility at 6 months

    Shoulder flexibility assessed with a goniometer

  8. Peak oxygen consumption

    Time frame: Change from baseline peak oxygen consumption at 6 months

    Peak oxygen consumption assessed with a metabolic cart during a progressive-intensity treadmill test

Study contacts

Contact information is provided by the study sponsor or research team.

John Ko, M.Sc.

CONTACT

[email protected]

306-966-1082

Philip Chilibeck, Ph.D.

CONTACT

[email protected]

306-966-1072

Sponsors and collaborators

Lead sponsor

University of Saskatchewan

Other

Collaborators

  • Canadian Institutes of Health Research (CIHR)

Registry information

Official study title

Is Stretching Superior to Aerobic Training for Reducing Blood Pressure?

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
Feb 23, 2022
Registry last updated
Apr 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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