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OpenTrials
Completed

NCT Number: NCT05413512

Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress

The present study will examine cardiovascular, metabolic, and neural responses to acute psychological stress using a cross-sectional approach.

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Key information

Conditions

Acute Psychological Stress

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Baylor University

Waco, Texas, 76799, United States

About this study

All participants in this study will undergo an acute psychological stress paradigm, consisting of two acute psychological stress tasks (MSIT and Stoop). There is no formal randomization since al participants are randomized to undergo the acute psychological stress tasks.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-30 years old

Exclusion criteria

  • Chronic medical or neurological condition
  • Pregnant
  • Current illness or infection
  • Any condition that would prohibit engaging in physical exercise
  • Any metal implants in body
  • Claustrophobia

Treatment and study plan

Acute psychological stress

Other

Experimental: Acute psychological stress Two, acute-psychological stress tasks known to reliably elicit a cardiovascular responses (Multi-source interference task; Stroop).

Primary outcomes

  1. Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline)

    Time frame: 18 minutes (approximately 9 minutes for each task)

    Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).

  2. Heart Rate (Bpm) Measured by Electrocardiogram

    Time frame: 18 minutes (approximately 9 minutes for each stress task)

    Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline).

  3. Neural Activity Measured by fMRI

    Time frame: 18 minutes (approximately 9 minutes for each stress task).

    Stressor-evoked neural activity.

    Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels.

Sponsors and collaborators

Lead sponsor

Baylor University

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jun 10, 2022
Registry last updated
Jun 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.