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Completed

NCT Number: NCT06480747

Strength Training and Muscle Lipids

The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength and power, motor unit activation, and lipid profiles of the vastus lateralis.

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Key information

Conditions

Healthy Behavior Motor Activity

Age range

8 year–10 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hoglund Biomedical Imaging Center, Kansas City, Kansas, United States

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteer males and females ages 8 - 10 years.

Exclusion criteria

  • No history or ongoing neuromuscular diseases.
  • No history or ongoing musculoskeletal injuries.
  • No history or ongoing disease that effects metabolism.

Treatment and study plan

Resistance Exercise Training

Other

Participants will strength train via linear periodization resistance exercise training.

Primary outcomes

  1. Change in muscular power of the leg extensors, as measured with isokinetic strength testing.

    Time frame: Baseline, following the intervention (9 weeks)

    The score will reflect the muscular power of the leg extensors. The higher score, reflects greater muscular strength.

Secondary outcomes

  1. Change from baseline in thigh muscle cross-sectional area

    Time frame: Baseline, following the intervention (9 weeks)

    Scores are measured cross-sectional area from ultrasound images. The higher score, reflects greater muscle size of the leg extensors.

Other outcomes

  1. Change from baseline in intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect a concentration. The higher score, reflects more fat in the fibers.

  2. Change from baseline in extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect a concentration. The higher score, reflects more fat in the fibers.

  3. Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect a saturation level of fatty acids in the extramyocellular lipid. The higher score, reflects greater fatty acid saturation.

  4. Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect a saturation level of fatty acids in the intramyocellular lipid. The higher score, reflects greater fatty acid saturation.

  5. Change from baseline in motor unit activation, as measured with surface electromyography decomposition.

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect the firing rates of recorded motor units. The higher score, reflects greater motor unit activation.

  6. Change in total body lean mass, as measured with bioelectrical impedance analysis.

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect the lean mass. The higher score, reflects greater lean mass.

  7. Change in total body fat mass, as measured with bioelectrical impedance analysis.

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect the fat mass. The higher score, reflects greater fat mass.

Sponsors and collaborators

Lead sponsor

University of Kansas Medical Center

Other

Collaborators

  • National Strength and Conditioning Association

Registry information

Official study title

The Effects of Strength Training on Neuromuscular Function and Muscle Lipids.

Acronym: Strength-Lip

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jun 28, 2024
Registry last updated
Aug 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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