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Completed

NCT Number: NCT02966600

Strength Training and Different Subtypes of Parkinson´s Disease

The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype). The investigators hypothesized the intervention would have a beneficial effect on the study outcomes.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University School of Sports Medicine, University of Oviedo, Spain.

Oviedo, Principality of Asturias, 33005, Spain

About this study

Twenty-eight patients with PD AR-type of both sexes, were recruited for this trial. Each participant were assigned randomly to either intervention (N=13) or control (N=15) group.

The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one. The control group followed their usual weekly physical activity routine.

All patients underwent antrophometrical and neuromuscular function assessment (CoP measurements -primary outcomes- and the Ten-Meters Walk Test -TMWT- -secondary outcomes-). In addition, they were asked to provide ratings for the Spanish validated versions of the the Freezing of Gait Questionnaire (FOG-Q, 6-item version) -secondary outcomes-, the 39-item Parkinson ́s disease Questionnaire (PDQ39) -secondary outcomes- and the MDS-UPDRS -secondary outcomes-. Additionally, ratings of perceived exertion (RPE) (Borg >6-20 scale) - secondary outcomes-, were recorded at the end of each PRE training session. Tests were carried out at three times: pre-test (before the training program), post-test (eight weeks after pre-tests, at the end of the training period), and four weeks after the post-test (re-test).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with PD AR-type and Hoehn and Yahr Scale 1-2, (H&Y)
  • Do not express any type of dementia
  • Able to stand for two min without assistance;
  • Able to walk ten metres without assistance.

Exclusion criteria

  • To suffer a neurological disease other than PD.
  • Do not meet some of the inclusion criteria.

Treatment and study plan

progressive resistance exercise

Other

The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one.

Physical activity

Other

The control group followed its usual weekly physical activity routine

Primary outcomes

  1. Static posturography through the centre of pressures measurements (CoP).

    Time frame: Eight weeks

Secondary outcomes

  1. Gait.

    Time frame: Eight weeks

  2. Freezing of gait.

    Time frame: Eight weeks

  3. The Movement Disorders Society-Unified Parkinson ́s Disease Rating Scale. (MDS-UPDRS).

    Time frame: Eight weeks

  4. The patient- perceived quality of life.

    Time frame: Eight weeks

Sponsors and collaborators

Lead sponsor

University of Oviedo

Other

Registry information

Official study title

Effects of Progressive Resistance Exercise in Akinetic-rigid Parkinson's Disease Patients

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Nov 17, 2016
Registry last updated
Nov 17, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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