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Completed

NCT Number: NCT02589990

Strength Training Adaptations, Age and Genes

The study investigates the effect of maximal strength training on muscular strength and power in different age groups from 20 to 80 year old. It also relates the training adaptations to different known genes such as angiotensin I-converting enzyme (ACE) and Alpha-actinin-3 (ACTN3). Participants will complete an eight weeks, three times per week training intervention of maximal strength training with a pre-post design. In addition, blood samples will be collected for the analyses of genetic variances.

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Key information

Conditions

Healthy

Age range

20 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Telemark University College, Bø, Telemark, Norway

Loading trial locations.

About this study

Aim: The study aims to investigate the effect of age and genes on training adaptations to a maximal strength training intervention.

Methods: Participants will be recruited through invitations at work places and other community arenas. The investigators aim to recruit 10-15 subjects in each of the following age groups: 20-29, 30-39, 40-49, 50-59, 60-69 and 70-80 years of age. Both genders will be included. All age groups will be matched for age-related baseline maximal strength and distribution between the two genders. All participants will be checked via a health registration scheme, and excluded if contra indications for hard physical training or testing should appear. When in doubt, the projects physician will decide on inclusion or exclusion due to a thorough examination. Subjects will give a blood sample to be analyzed for known genes such as ACE and ACTN3. The intervention has a pre- post design. Tests of maximal strength and power will be conducted in a leg-press machine, using the protocol assessing one repetition maximum (1RM) previously described. Force and Power will be measured by the Muscle Lab system from Ergotest Tech. (Langesund, Norway). The intervention is an eight week, three times per week protocol, each training session consisting of a standardized warm-up, and 4 repetitions x 4 sets with an intensity of 4 repetition maximum (4RM) performed in the leg press machine.There will be a three minutes pause between sets. Participants will be given instructions and supervision.

Hypothesis: Maximal strength training adaptations will be affected by age and baseline maximal strength but not by gender or genetic variations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults 20 to 90 years old

Exclusion criteria

  • Contraindications to maximum strength training and testing

Treatment and study plan

strength training

Behavioral

see arm description

Primary outcomes

  1. Maximal muscle strength measured by 1 RM leg press in leg press machine

    Time frame: 8 weeks

Secondary outcomes

  1. Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen

    Time frame: 8 weeks

  2. rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway)

    Time frame: 8 weeks

  3. agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway)

    Time frame: 8 weeks

Sponsors and collaborators

Lead sponsor

University of South-Eastern Norway

Other

Collaborators

  • Norwegian University of Science and Technology

Registry information

Official study title

Effect of Maximal Strength Training in Relation to Age and Genes

Acronym: STAGE

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Oct 28, 2015
Registry last updated
Sep 28, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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