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OpenTrials
Completed

NCT Number: NCT00667134

Stimulatory Autoantibodies to the Platelet-Derived Growth Factor Receptor (PDGFR) in Patients With Systemic Sclerosis

This study is to determine if subjects with .systemic sclerosis have stimulatory autoantibodies to the PDGF receptor and to confirm activation (phosphorylation) of the PDGF receptor in skin sites with varying degrees of skin thickening

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Key information

Conditions

Systemic Sclerosis Connective Tissue Diseases Scleroderma, Systemic Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–99 year

Sex eligibility

Female

Study type

Observational

Primary location

University of Michigan Medical School

Ann Arbor, Michigan, 48103, United States

About this study

Pilot study to assess whether patients with systemic sclerosis have stimulatory autoantibodies to the PDGF receptor and to confirm activation (phosphorylation) of the PDGF receptor in skin sites with varying degrees of skin thickening

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Fulfill the American College of Rheumatology criteria for systemic sclerosis or:
  • Have no diseases that result in primary fibrosis of an organ system, including the skin and do not have an autoimmune disease

Exclusion criteria

  • If the subject has systemic sclerosis resulting from an environmental exposure
  • If the subject has an autoimmune disease excluding scleroderma
  • If the subject has an active infection (including, but not limited to hepatitis B, hepatitis C and HIV)
  • If the subject has been treated with cyclophosphamide in the past 8 weeks.
  • If the subject is prone to bleeding because they are on medications that thin the blood or have a low platelet count.

Treatment and study plan

Primary outcomes

  1. Stimulatory autoantibodies to the PDGF receptor

    Time frame: 1 year

Secondary outcomes

  1. Phosphorylation of the PDGF receptor in patients with systemic sclerosis

    Time frame: One year

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Collaborators

  • Pfizer

Registry information

Official study title

Stimulatory Autoantibodies to the PDGFR and Phosphorylation of the PDGFR in Patients With Systemic Sclerosis

Important dates

Study start
2008
Primary completion
2008
Study completion
2012
First posted
Apr 25, 2008
Registry last updated
Oct 26, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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