Stimulating the Aging Brain Using Brain and Sensory Stimulation

The primary objective of the current project is to examine the effects of tACS and multisensory stimulation on verbal STM outcomes in individuals with PPA. The selection of parameters will be guided on the basis of oscillatory brain activity using language task-based or task-free EEG paradigms. Neuroimaging (MRI and functional MRI) will guide spatial targets of tACS. A secondary objective is to explore sources of individual variability in response to stimulation and whether these factors could offer insight into disease progression. This proof-of-concept, pilot project will generate essential preliminary data to help refine hypotheses for future clinical trials aimed at assessing the efficacy of these intervention strategies in predicting and treating (as in delaying) disease progression.

Inclusion criteria

• Clinical exam supports diagnosis of PPA and/or MCI with no report of difficulty functioning in basic or instrumental activities of daily living.
• Completed clinical cognitive exam within 6 months of study baseline visit OR neuropsychological research battery within 6 months of study baseline visit.

Exclusion criteria

• Evidence of dementia at baseline
• Known history of neoplasm, symptomatic stroke, moderate to severe traumatic brain injury, or other significant neurologic event
• Age <45 years.
• Evidence of severe psychiatric illness (e.g., bipolar disorder, schizophrenia).
• Presence of cardiac stimulators or pacemakers
• Any other implants near the scalp or in the eye
• Contraindications to MRI or stimulation
• Pregnancy
• History of ongoing or unmanaged seizures
• History of dyslexia or other developmental learning disabilities