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NCT Number: NCT06432907

StereoEEG Motor Neuronal Potentials Decoding

The goals of this study are (1) to evaluate the rate of stereoEEG brain-computer interface (BCI) classification accuracy and (2) to collect the dataset of neuronal signals recorded from stereoEEG electrodes during motor performance, motor imagery or brain-computer interface control. The study enrolls hospitalised patients suffering from resistant epilepsy with already implanted intracranial stereoEEG electrodes for medical reasons (i.e. for preoperative localization of the epileptogenic foci). The number and location of electrodes are determined solely for the clinical purposes of stereoEEG monitoring and are not related to the protocol of the current study.

After obtaining informed consent to participate in the study, each patient will participate in one experimental session lasting no more than 60 minutes, recording brain signals associated with hand movement, motor imagery, and BCI control. All tasks and instructions presented during the study session are not pro-epileptogenic and cannot provoke an epileptic attack. The experiments will take place in the patient's room, without interruption of observation by the department's medical staff.

The data recorded in this study will be used to improve or develop new algorithms for decoding motor signals from deep brain structures for their potential use in invasive BCIs.

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Key information

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Research center of neurology, Department of neurorehabilitation and physiotherapy

Moscow, 125367, Russia

Location status: Recruiting

Location contact

Natalia A Suponeva, MD

CONTACT

[email protected]

+79161894988

Olesya A Mokienko, MD PhD

SUB_INVESTIGATOR

Roman Kh Lyukmanov, MD PhD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male and female patients who have had stereoEEG electrodes implanted for medical reasons;
  • voluntary informed consent to participate in the study;
  • age from 18 to 70 years.

Exclusion criteria

  • patient refusal to participate in the study;
  • cognitive impairment that prevents following the study instructions;
  • severe visual impairment that does not allow viewing visual instructions on a computer screen;
  • upper limb paresis or other motor disorders;
  • pain in the hand of any etiology;
  • any acute diseases, exacerbation of chronic diseases, acute life-threatening conditions;
  • occurrence of an epileptic attack during the experiment.

Treatment and study plan

motor tasks

Other

During the study session, the patient will sit at a table in front of a computer monitor. The stereoEEG electrodes will be connected to the Neurovisor-BMM52 electroencephalograph (Medical Computer Systems, Russia) and to a computer with a software for recording and decoding brain signals (BCI classifier). One microsensor (Ascension TrekStar, Ascension Technology, USA) and two disposable cutaneous electrodes (connected to the Neurovisor-BMM52 system) will be put on each patient's hand for electromyogram recording.

The session consists from 3 blocks (1-3). The participant is asked to:

  • execute simple motor tasks (thumbs up, open hand or clench hand into fist - 30 times with each hand with 5-second brakes), according to the instruction on the computer screen;
  • to imagine the same movements - 30 times with each hand with 5-second brakes;
  • to imagine the same movements with the feedback (brain-computer interface control).

The blocks are separated by 5-minute brakes.

Other names: motor execution, motor imagery, brain-computer interface control with motor imagery paradigm

Primary outcomes

  1. Rate of BCI classification recall

    Time frame: During the procedure

    The proportion (%) of cases with correct identification of the task among all presentations of the corresponding command.

Study contacts

Contact information is provided by the study sponsor or research team.

Olesya A Mokienko, MD PhD

CONTACT

[email protected]

+74953747776

Roman Kh Lyukmanov, MD PhD

CONTACT

[email protected]

+74953747776

Sponsors and collaborators

Lead sponsor

Research Center of Neurology, Russia

Other Gov

Collaborators

  • Institute of Higher Nervous Activity and Neurophysiology of RAS

Registry information

Official study title

Decoding of Neuronal Potentials Associated With Motor Performance and Motor Imagery Obtained Using Intracranial stereoEEG Electrodes

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
May 29, 2024
Registry last updated
Jul 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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