Beijing Tian Tan Hospital
Beijing, 100070, China
NCT Number: NCT07274683
The goal of this clinical trial is to learn about the effect of preoperative administration of stellate ganglion block on postoperative sleep status in patients with prolonged disorders of consciousness. The main aims to answer are: • To explore the effect of preoperative administration of stellate ganglion block on postoperative polysomnography and total sleep time in patients with prolonged disorders of consciousness. • To explore the effect of preoperative administration of stellate ganglion block on postoperative cerebral oxygen saturation, cerebral hemodynamic parameters and recovery of consciousness. Participants will be pDoC patients with intact skulls after acquired brain injury who will undergo spinal cord electronic stimulator implantation under general anesthesia at Beijing Tiantan Hospital. Stellate ganglion block will be administrated before the surgery. Polysomnography, total sleep time, cerebral oxygen saturation, cerebral hemodynamic parameters, CRS-R scores, GCS scores, WHIM scores and NCS scores will be investigated.
Trial opening soon.
Get Notified18 year–65 year
All sexes
Observational
Beijing, 100070, China
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
A single dose of ultrasound-guided stellate ganglion block with 0.5% ropivacaine was administered to the pDoC patients after induction of general anesthesia but before surgical incision.
Time frame: on the first postoperative night
total sleep time on PSG
Time frame: 30 minutes after stellate ganglion block
Regional cerebral oxygen saturation (rSO₂) measured by near-infrared spectroscopy (NIRS).
Time frame: 30 minutes after stellate ganglion block.
cerebral hemodynamic parameters measured by Transcranial Doppler(TCD)
Time frame: 1 and 30 days postoperatively
Consciousness recovery will be assessed using the Coma Recovery Scale-Revised (CRS-R). It assesses patients across six functional domains: auditory, visual, motor, oromotor/verbal, communication, and arousal. The total score ranges from 0 to 23, with higher scores indicating a higher level of consciousness.
Time frame: 30 days postoperatively
Time frame: 30 days postoperatively
Contact information is provided by the study sponsor or research team.
Beijing Tiantan Hospital
Other
Effect of Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness: a Single--Centre Cohort Study
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