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OpenTrials
Completed

NCT Number: NCT05962385

State Dependence of Prefrontal Transcranial Magnetic Stimulation

The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation. The study includes two separate sessions and people will complete either a cognitive task or a perceptual task while receiving transcranial magnetic stimulation. The study will measure change in brain function with EEG.

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Key information

Conditions

Healthy

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 - 65,
  • healthy controls

Exclusion criteria

  • Diagnosed psychiatric disorder
  • Potential contraindications to EEG (e.g. visible scalp abrasions, non-removable hair extensions and/or hair styling that would impede proper EEG recording)
  • Potential contraindication to TMS (as identified by the TMS safety screener)
  • Any previous adverse reaction to TMS or MRI
  • Diagnosed epilepsy or previously experienced a seizure
  • Diagnosed neurological condition, such as stroke or tinnitus
  • Experienced a head trauma that was diagnosed as concussion
  • Current use of, or recent withdrawal from, medications that can increase the risk of seizure
  • Currently pregnant
  • Any metal in the head (excluding mouth)
  • Any implanted medical device

Treatment and study plan

Brain state while receiving TMS

Device

Brain state whilst receiving TMS - cognitive control or perceptual. Repeated measures design, so all participants receive the same procedures.

Primary outcomes

  1. Theta-gamma cross frequency coupling

    Time frame: 0-500 ms after each TMS stimulus

    A metric of brain function measured with EEG - the coupling of theta oscillation phase with gamma power. This will be measured immediately following the intervention (TMS stimulation).

  2. Cortical excitability

    Time frame: 60-300 ms after each TMS stimulus

    TMS-evoked potentials will be measured with EEG to examine cortical excitability after TMS. This will be measured immediately following the intervention (TMS stimulation).

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jul 27, 2023
Registry last updated
Dec 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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