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NCT Number: NCT07610785

Standardized Adaptive Music Medicine for Suicidality

The primary goal of this clinical trial is to test if music-based intervention (STAMM-S) works for individuals with suicidal thoughts or behaviors. The main questions it aims to answer are:

* Can implementing specific music to listen to for 20 minutes a day for 25 days improve suicidality? * Can implementing education around the psychology of the medicine of music improve mental health outcomes?

Participants will:

* Listen to music given to them by the study team for 20 minutes a day for 25 days * Receive musical psychoeducation on how to improve mood using music

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Key information

Conditions

Suicidal Thoughts and Behaviors Behavior Behavioral Symptoms Self-Injurious Behavior Suicidal Ideation Suicide

Age range

14 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yuukis Hall - Stanford University

Palo Alto, California, 94304, United States

Location contact

Daniel L Bowling, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 14-35 years
  • Suicidal ideation (C-SSRS categories 1-3 within the past month)
  • normal sensitivity to music reward on the Barcelona Music Reward Questionnaire. Score >65

Exclusion criteria

  • imminent or acute suicide risk (C-SSRS categories 4-5).
  • Co-morbid substance use disorder.
  • Co-morbid psychotic disorder.
  • current participation in another trial

Treatment and study plan

STAMM-S

Behavioral

Participants will undergo the STAMM-S treatment, which involves music generated using machine learning to move to a more positive affect. They will also receive education on how to best use the music assigned to improve their mood.

Primary outcomes

  1. Change in Suicidality via Beck Scale for Suicidal Ideation (BSS/BSSI) Score

    Time frame: Baseline, week 1, week 2, week 3, and post-trial interview (up to 25 days).

    A 19-item scale with each item scoring from 0-2 rating an individual's suicidal thoughts, intent, and ideation. The total score ranges from 0 to 38. A higher score indicates more intense suicidal ideation and a low score indicates less intense suicidal ideation.

  2. Change in Generalized Anxiety Disorder Status via Generalized Anxiety Disorder-7 (GAD-7) Score

    Time frame: Baseline, week 1, week 2, week 3, and post-trial interview (up to 25 days).

    A 7-item measure scaled 0-3 per item that measures symptoms of Generalized Anxiety Disorder. 0 would be no sign of anxiety and 3 would indicate high level of anxiety over the last two weeks.

  3. Change in Depression Status via Patient Health Questionnaire-9 (PHQ-9) Score

    Time frame: Baseline, week 1, week 2, week 3, and post-trial interview (up to 25 days).

    A 9-item questionnaire that measures symptoms of depression on a 0-3 scale over the last two weeks. 0 would indicate "not at all", 1 would indicate "several days", 2 would indicate "most of the days", and a 3 would indicate "nearly every day".

Secondary outcomes

  1. Change in Music Listening Purpose via Healthy-Unhealthy Music Scale (HUMS) - Healthy Score

    Time frame: Baseline, end of study (up to 25 days).

    Participants respond to a 5-question survey. The scale ranges from 5 to 25. For the healthy scale, a higher rating means a healthier use of music.

  2. Change in Music Listening Purpose via Healthy-Unhealthy Music Scale (HUMS) - Unhealthy Score

    Time frame: Baseline, end of study (up to 25 days).

    Participants respond to an 8-question survey. The scale ranges 8 to 40. A higher rating for the unhealthy scale indicates a more maladaptive use of music.

  3. Acceptability Scale Score

    Time frame: At the end of the intervention (25 days after enrollment).

    A 7-question questionnaire on a scale of 0-7 covering the 7 core components on intervention acceptability, where a 0 would indicate total unacceptability and 7 would equal total acceptability. Single participant rating of 4 or greater will be interpreted as satisfactory acceptability.

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Acronym: STAMM-S

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
May 28, 2026
Registry last updated
May 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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