Skip to main content
OpenTrials
Completed

NCT Number: NCT01673958

Stair Descending vs. Stair Ascending Exercise

The aim of the present project is to compare the acute and chronic effect of stair descending versus stair ascending exercise on muscle damage and performance in elderly males with chronic heart failure.

Completed

Looking for future studies?

Notify Me

Key information

Age range

60 year–70 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

European University Cyprus

Nicosia, 1516, Cyprus

About this study

Study design:

Twelve elderly males with chronic heart failure, New York Heart Association class I-II, will participate in this study. Participants will be allocated into two equally-sized groups: a stair descending group (n = 6) and a stair ascending group (n = 6). At the beginning of the study, the volunteers will perform an acute bout of stair descending or stair ascending exercise on an automatic escalator (4 sets of 3 min each, speed will be set at 45 steps∙min-1). Step height will be 20.5 mm. Before and at day 2 post exercise, physiologic measurements will be performed and blood samples will be collected. Then, participants will carry out six weeks of stair descending or ascending training consisting of three exercise sessions per week (the first two weeks the speed will be set at 45 steps∙min-1, the next two weeks at 50 steps∙min-1 and the last two weeks at 55 steps∙min-1 for both groups). Afterward, they will repeat the acute stair descending or ascending protocol, as carried out at the beginning of the study, and the same physiologic measurements will be performed and blood samples will be collected.

Measurements:

Isometric (at 90 knee flexion), concentric and eccentric peak torque at 60o∙s-1of quadriceps femoris, pain-free range of motion, delayed onset muscle soreness and creatine kinase will be measured.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • chronic heart failure (New York Heart Association class I-II)
  • subject provides written informed consent
  • personal physician of the participants provides written informed consent

Exclusion criteria

  • smoker
  • consumed any nutritional supplement the last 3 months
  • performed intense eccentric exercise the last 6 months
  • non Caucasian

Treatment and study plan

Exercise

Other

Comparison between stair descending and stair ascending training

Primary outcomes

  1. Muscle strength (torque)

    Time frame: Change from baseline in muscle strength at day 2 post exercise at the first and sixth week of training

    An isokinetic dynamometer (Cybex, Ronkonkoma, NY) will be used for the measurement of isometric, eccentric and concentric knee extensor peak torque at 90° knee flexion. The average of the three best maximal voluntary contractions with their dominant leg will be recorded. In order to ensure that the subjects provide their maximal effort, the measurements will be repeated if the difference between the lower and the higher torque value exceeded 10%. There will be two minutes rest between isometric efforts.

Secondary outcomes

  1. Pain free range of motion (degrees)

    Time frame: Before and at day 2 post exercise at the first and sixth week of training

    The assessment of pain-free ROM will be performed manually using the the isokinetic dynamometer. The investigator will move the calf at a very low angular velocity from 0 knee extension to the position where the subject will feel any discomfort.

  2. Creatine kinase, CK (activity IU)

    Time frame: Before and at day 2 post exercise at the first and sixth week of training

    CK activity will be measured as a general indicator of muscle damage.It will be measured in a Cobas Integra Plus 400 chemistry analyzer.

  3. Delayed onset muscle soreness, DOMS (scale 1-10)

    Time frame: Before and at day 2 post exercise at the first and sixth week of training

    Each participant will assess delayed onset muscle soreness (DOMS) during squat movement (90o knee flexion) and perceived soreness will be rated on a scale ranging from 1 (normal) to 10 (very sore).

Sponsors and collaborators

Lead sponsor

European University Cyprus

Other

Collaborators

  • Aristotle University Of Thessaloniki
  • University of Thessaly

Registry information

Official study title

The Effect of Stair Descending and Stair Ascending Exercise on Muscle Strength and Performance: the SmartEscalator Device

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Aug 28, 2012
Registry last updated
Aug 28, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.