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Completed

NCT Number: NCT05263115

Stair Climbing Exercise Versus Traditional Resistance Exercise

Current evidence suggests resistance exercise as the primary therapeutic strategy to prevent age-related functional decline. The National Strength and Conditioning Association recently stated that a properly designed resistance exercise program should include power exercises performed at higher velocities in concentric movements with moderate intensities. We should be aware that not all older adults are easily motivated to train in unfamiliar gym-based settings with high subscription fees. Therefore, implementation of traditional gym-based resistance exercise at a large scale has been found to be difficult. Interestingly, we have previously shown that the use of high external loads, which implies the need for specific facility memberships, is not necessary to induce neuromuscular gains. This provides strong support for home-based training intervention strategies. Stair climbing or stepping-based exercise constitute a promising avenue to ameliorate the cost-effectiveness and implementation potential of resistance exercise in older adults. Such exercises can induce muscular activation levels similar to high-load resistance exercise and result in similar or even better gains in muscle mass, strength and power compared to slow-speed resistance exercise when properly designed. However, the (neuro)-muscular effects of stair climbing exercise have never been compared to the more optimal power-oriented resistance exercise, which is the primary aim of this study. The secondary aim of this study is to examine if stair climbing exercise also has beneficial effects on cognition.

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Key information

Conditions

Age range

65 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Movement Sciences

Leuven, 3001, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-

Exclusion criteria

  • Unstable cardiovascular disease
  • Neurological disorders
  • Cognitive malfunctioning (MoCA < 24)
  • Low level of physical function (SPPB < 7)
  • Acute infections/fever
  • Severe musculoskeletal problems
  • Systematic engagement in (resistance) exercise in the 12 months prior to participation

Treatment and study plan

Resistance Exercise intervention

Other

12-week progressive resistance exercise intervention

Functional stair climbing and stepping-based exercise intervention

Other

12-week progressive stair climbing and stepping-based exercise intervention

Primary outcomes

  1. F-V profile

    Time frame: Change from baseline in F-v profile at 12 weeks

    Force-velocity profiling is carried out unilaterally (dominant leg) on the pneumatic leg press device (Leg Press CC, HUR, Kokkola, Finland). The test protocol consists of a maximal isometric test (knee joint angle = 85°, hip angle = 55°; 3 attempts of 3s), followed by explosive concentric leg extensions at gradually increasing loads (unloaded, 15%, 30%, 45%, 60%, 75% of the maximal isometric force, 2-3 attempts per load, and additional single repetitions until one-repetition maximum is reached). Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced adaptations. F0 (maximal force), v0 (maximal velocity), a (the equation's slope), Pmax (maximal power) and the corresponding v and F at Pmax are used for the analyses.

Secondary outcomes

  1. Gait speed

    Time frame: Change from baseline in gait speed at 12 weeks

    The average speed to walk 10m as fast as possible (in m/s)

  2. 5-repetition sit-to-stand time

    Time frame: Change from baseline in sit-to-stand performance at 12 weeks

    The time (s) needed to perform 5 sit-to-stand transitions.

  3. 5-repetition sit-to-stand power

    Time frame: Change from baseline in sit-to-stand performance at 12 weeks

    The power (watt) needed to perform 5 sit-to-stand transitions.

  4. Stair ascent time

    Time frame: Change from baseline in stair climbing performance at 12 weeks.

    The time (s) needed to ascend a flight of stairs.

  5. Stair ascent power

    Time frame: Change from baseline in stair climbing performance at 12 weeks.

    The power (watt) needed to ascend a flight of stairs.

  6. Countermovement jump height

    Time frame: Change from baseline in countermovement jump height at 12 weeks.

    Jump height (cm) in a countermovement jump

  7. MoCA test score

    Time frame: Change from baseline in Montrial Cognitive Assessment test score at 12 weeks.

    Total score (min 0, max 30, higher scores indicate better performance) on the Montreal Cognitive Assessment test

  8. Digit Span Test score

    Time frame: Change from baseline in Digit Span Test score at 12 weeks.

    Total score (min 0, max 30, higher scores indicate better performance) on the Digit Span Test

  9. Trail Making Test Time

    Time frame: Change from baseline in Trail Making Test at 12 weeks.

    Total duration (s) needed to complete the Trail Making Test.

  10. Stroop Test number of words

    Time frame: Change from baseline in Stroop Test at 12 weeks.

    Total number of words red in 45s in the stroop test.

Sponsors and collaborators

Lead sponsor

KU Leuven

Other

Registry information

Official study title

An Individualized Stair Climbing Program Versus Traditional Resistance Exercise: Effects on Strength, Power, Functional Performance and Cognition in Older Adults

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Mar 2, 2022
Registry last updated
Jan 23, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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