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NCT Number: NCT07349342

Stable Versus Unstable Resistance Training Effects on Physical Fitness and Physiological Biomarkers of Untrained Male University Students

The goal of this clinical trial is to learn the effects of stable and unstable resistance training on physical fitness, kidney function and blood lipid tests in healthy young male volunteers. The main questions it aims to answer are:

* Do both stable and unstable resistance training increase the level of urinary protein clearance greater than the control group? * What is the difference in improvement of lipid profiles among the groups? * Does unstable resistance training mode rise muscular endurance greater than stable resistance training?

Researchers will compare stable and unstable resistance training to see if there are differences on physical fitness measures, blood lipid and urinary protein tests.

Participants, in their respective group will receive ten weeks of:

* Stable resistance training * Unstable resistance training or * No exercise training intervention

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This study is active but is not currently recruiting participants.

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Key information

Conditions

No Condition Health Young Males

Age range

20 year–24 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Kotebe University of Education

Addis Ababa, Yeka Sub City, Ethiopia

About this study

This study included volunteer male untrained students living at Kotebe University of Education. Priori statistical power analysis (G*Power version 3.1.9.2, Stuttgart, Germany) was used to estimate the sample size. Based on earlier research, a moderate to high effect size (0.295) was assumed, and considering a dropout probability of 10%, a sample of 54 participants was enough to meet adequate statistical power. All participants provided written informed consent to participate in this study. The training protocol will include ten resistance exercises for each intervention, performed three times a week for 10 weeks. Each session lasts 60 minutes, including a 10 to 15-minute warm-up, a 40-minute main exercise targeting core, upper, and lower limb muscles, and a 5 to 10-minute cool-down and stretching. The protocol will adhere to basic training principles like overload, progression, and specificity. The training will take place in the university gymnasium. The study will be conducted in accordance with local legislation and institutional requirements. It will be strictly governed by the ethical principles of the Declaration of Helsinki.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No resistance training within the previous six months
  • Completing a written informed consent document
  • Responding to the physical activity readiness questionnaire (PAR-Q) and becoming convenient

Exclusion criteria

  • A history of musculoskeletal injury
  • Chronic diseases, including known kidney disease
  • A habit of alcohol or drug abuse

Treatment and study plan

Resistance training

Other

stable resistance training is represented by traditional resistance training using equipment like medicine ball, resistance machine and own body mass

Primary outcomes

  1. Urinary Albumin

    Time frame: At baseline and after 10 weeks of resistance training interventions

    • It will be measured using random urine samples in milligrams per liter
    • The minimum value is 0, the maximum is 20
    • A higher score means a worse outcome

  2. Urinary Creatinine

    Time frame: At baseline and after 10 weeks of training intervention

    • It will be measured using random urine samples in millimoles per liter
    • The minimum value is 3, the maximum is 25.
    • A higher score means a better outcome

  3. Urinary albumin to creatinine ratio

    Time frame: At baseline and after 10 weeks of resistance training interventions

    • Urinary albumin to creatinine ratio is computed by dividing the obtained urinary albumin by urinary creatinine
    • It is measured in milligrams per millimole
    • The minimum value is 0, the maximum is 3
    • A high score means a worse outcome

  4. Serum Creatinine

    Time frame: At baseline and after 10 weeks of resistance training intervention

    • It is measured using a fasting blood sample in micromoles per liter
    • The minimum value is 50, the maximum is 110
    • A higher score means a worse outcome

  5. Estimated Glomerular Filtration Rate

    Time frame: At baseline and after 10 weeks of resistance training interventions

    • Estimated glomerular filtration rate is computed using a serum creatinine-based equation
    • The scores are reported in milliliters per minute per 1.73 square meters
    • The minimum value is 90, the maximum is 130
    • A higher score means a better renal function

  6. High-Density Lipoprotein Cholesterol

    Time frame: At baseline and after 10 weeks of resistance training

    • It is measured using a fasting blood sample tests in millimoles per liter
    • The minimum value is 1, the maximum is greater than or equal to 2
    • A higher score means a protective and better outcome

  7. Low-Density Llipoprotein Cholesterol

    Time frame: At baseline and after 10 weeks of resistance training

    • It is measured using a fasting blood sample in millimoles per liter
    • The minimum value is 0, the maximum is 2.6
    • A higher score means a worse outcome

  8. Total Cholesterol

    Time frame: At baseline and after 10 weeks of resistance training

    • It is measured using a fasting blood sample test in millimoles per liter
    • The minimum score is 0, the maximum is 5.2
    • A higher score means a worse outcome

  9. Triglycerides

    Time frame: At baseline and after 10 weeks of resistance training

    • Triglycerides are measured using a fasting blood sample test in millimoles per liter
    • The minimum value is 0, the maximum is 1.7
    • A higher score means a worse outcome

  10. Hand Grip Strength

    Time frame: At baseline and after 10 weeks of training intervention

    • Hand grip strength test will be used to measure muscular strength
    • It is measured in kilograms
    • The minimum value is 27, the maximum is 56
    • A higher score means a better outcome

  11. Muscular Endurance

    Time frame: At baseline and after 10 weeks of training intervention

    • Push-up and sit-up tests will be used to measure muscular endurance
    • The number of repetitions is a unit for both tests
    • The minimum score for push-up is 20, the maximum is 40
    • The minimum value for sit-up is 25, the maximum is 45
    • A higher score means a better outcome

  12. Core Endurance

    Time frame: At baseline and after 10 weeks of training intervention

    • The McGill core endurance test will be conducted and reported in seconds
    • The minimum value is 45, the maximum is 120
    • A higher score means a better outcome

  13. Flexibility

    Time frame: At baseline and after 10 weeks of training intervention

    • Sit and reach test will be conducted and reported in centimeters
    • The minimum value is 20, and the maximum is 35
    • A higher score means a better outcome

  14. Body Fat Percentage

    Time frame: At baseline and after 10 weeks of training intervention

    • It will be estimated using 3 site skin fold measures in millimeters
    • Body density will be calculated by the Jackson & Pollock equation
    • The obtained density is converted into body fat percentage using the Sir equation
    • The minimum value is 10, the maximum is 22
    • A higher score means aworse outcome

Sponsors and collaborators

Lead sponsor

Addis Ababa University

Other

Registry information

Official study title

Comparative Effects of Stable Versus Unstable Resistance Training on Lipid Profile Selected Physical Fitness and Renal Biomarkers of Untrained Male University Students

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 16, 2026
Registry last updated
Jan 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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