ST-Segment Resolution as a Marker for Myocardial Scar in ST-Segment Elevation Myocardial Infarction

Clinical studies found that poor ST-segment resolution (STR) in electrocardiogram (ECG) occurred in major adverse cardiovascular events (MACE), arrhythmia and heart failure was significantly higher . In clinical work, in patients have poor ST-segment decline, the investigators found by CMR-LGE the corresponding myocardium become thinner and other signs of myocardial scar.

The investigators aimed to establish whether poor ST-segment resolution in ECG, as well as CMR-LGE, could detect the presence of myocardial scar in early STEMI patients. In order to provide convenient, cheap and widely used test method for patients who cannot tolerate CMR-LGE.

42 STEMI patients with single-branch coronary artery stenosis or occlusion were enrolled. ST-segment elevations were measured on the baseline and 24 hours after PCI. The study population was divided into two groups by late gadolinium enhanced cardiac magnetic resonance (LGE- CMR), with transmural myocardial scar (>75%) or non-transmural myocardial scar (<75%).

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Key information

Conditions

Cardiovascular Diseases

Age range

30 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The first affiliated hospital of Chongqing medical university

Chongqing, Chongqing Municipality, 400016, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Single-branch coronary artery stenosis or occlusion
Restoration of coronary perfusion to TIMI flow grade 3 after PCI

Exclusion criteria

A prior history of the acute coronary syndrome
Coronary revascularization
Severe chronic kidney disease
Intracardiac pacing leads or other implants precluding CMR-LGE
Hemodynamic instability
Known claustrophobia

Treatment and study plan

ST-segment resolution <40.15%

Diagnostic Test

Forty-two STEMI patients with single-branch coronary artery stenosis or occlusion were enrolled. ST-segment elevations were measured at emergency admission and at 24 h after PCI. Late gadolinium-enhanced cardiac magnetic resonance imaging (CMR-LGE) was performed 7 days after PCI to evaluate myocardial scars.

Primary outcomes

ST-segment resolution<40.15%

Time frame: 1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed.

CMR-LGE was performed to evaluate myocardial scars.
ST-segment resolution>40.15%

Time frame: 1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed.

CMR-LGE was performed to evaluate myocardial scars.

Sponsors and collaborators

Lead sponsor

Chongqing Medical University

Other

Registry information

Official study title

The First Affiliated Hospital of Chongqing Medical University.

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2019
First posted: Oct 14, 2020
Registry last updated: Oct 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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