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Completed

NCT Number: NCT05073211

St. John's Wort Photodynamic Therapy

The investigators aimed to evaluated the efficacy and safety of SJW-PDT compared to indole-3-acetic acid (IAA)-PDT in the treatment of acne. The investigators also investigated the skin rejuvenating effects of SJW-PDT.

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Key information

Conditions

Acne Acne Vulgaris Acneiform Eruptions Sebaceous Gland Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

25 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Bundang Hospital

Seongnam, 13620, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with mild to moderate facial acne
  • between 25 and 60 years old

Exclusion criteria

  • history of oral retinoid treatment with the past 6 months
  • history of oral antibiotics, topical acne treatment, or skin rejuvenation treatment such as lasers and chemical peeling within the month before the start of the study

Treatment and study plan

PDT

Procedure

A 630 nm red light and a 520 nm green light of the light-emitting diode (LED) device (Nouvo-GB®) with an intensity of 35 mW⁄cm2 was simultaneously illuminated for 10 minutes (a total light dose of 21 J/cm2). Participants received a total of four treatments at 1-week intervals and were followed up 1 and 4 weeks after the last treatment.

Primary outcomes

  1. acne lesions

    Time frame: 1 and 4 weeks after the last treatment

    change in the number of acne lesions after the treatment

Secondary outcomes

  1. sebum secretion rate (μg/cm2)

    Time frame: 1 and 4 weeks after the last treatment

    Sebum secretion rate was measured with Sebumeter SM 815®.

Other outcomes

  1. erythema index (arbitrary unit)

    Time frame: 1 and 4 weeks after the last treatment

    The erythema index (EI) was measured with Mexameter MX 1® (Courage & Khazaka)

  2. skin texture, wrinkles (arbitrary unit)

    Time frame: 1 and 4 weeks after the last treatment

    The skin texture and wrinkles were measured with an Antera 3D® camera (Miravex Limited, Dublin, Ireland).

Sponsors and collaborators

Lead sponsor

Seoul National University Bundang Hospital

Other

Registry information

Official study title

A Randomized Split-face Study of Photodynamic Therapy With St. John's Wort Versus Indole-3-acetic Acid for the Treatment of Acne

Acronym: SJWPDT

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Oct 11, 2021
Registry last updated
Oct 11, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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