Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)

The purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Completed

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Key information

Conditions

Chronic Stable Heart Failure Cardiovascular Diseases Glucose Metabolism Disorders Heart Diseases Heart Failure Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

About this study

Diuretics is useful in CHF patients. On the other hand, they deteriorate glucose metabolism. Therefore, the purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

chronic stable heart failure

Exclusion criteria

renal dysfunction or under treatment with antidiabetic agents

Treatment and study plan

spironolactone + furosemide

Drug

spironolactone 25mg/day, 16 weeks and furosemide 20mg/day, 16weeks

Primary outcomes

insulin resistance

Time frame: 16 weeks

Sponsors and collaborators

Lead sponsor

Tottori University Hospital

Other

Registry information

Official study title

Effects of Spironolactone on Insulin Resistance in Patients With Chronic Heart Failure

Important dates

Study start: 2004
Study completion: 2005
First posted: Apr 22, 2008
Registry last updated: Apr 22, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed