Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass

CONTEXT: In patients eligible for coronary artery bypass surgery, anesthesia should provide a number of conditions that exceed the limits of cardiovascular stability, myocardial protection and other organs. Moreover, the combination of general anesthesia and spinal anesthesia lessens the homeostatic, metabolic, hormonal and immunosuppressive changes. The goal of this research was to evaluate the consumption of fentanyl citrate in intra-operative in Coronary Artery Bypass Grafting (CABG) surgery with cardiopulmonary bypass under spinal anesthesia associated with general anesthesia.

METHODS: Clinical, prospective, randomized and double covered study, approved by the Research Ethics Committee. Fifty-six patients candidates for CABG with CPB, after signing the Terms of consent, were randomized and divided into two groups: GI - General and GII - General + subarachnoid. General anesthesia was induced according to the weight of each patient and maintenance with isoflurane and fentanyl. Spinal anesthesia was induced with 20 mg of 0.5% hyperbaric bupivacaine and 200 mcg of morphine, the patient is placed in cephalo-position slope of 45 degrees for 10 minutes in Group II. In the statistical study was performed using the Mann-Whitney test; the level of statistical significance was set at 5%.

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Key information

Conditions

Myocardial Revascularization Fentanyl Postoperative Care Spinal Anesthesia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Hospital das Clinicas Samuel Libânio, Pouso Alegre, Minas Gerais, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients of both genders
Underwent cardiac artery bypass surgery with cardiopulmonary bypass, with
No restriction on age
No restriction on ethnicity
No restriction on education or social class

Exclusion criteria

Patients with sternotomy provided; those
Urgent surgery and/or emergency
Patient was with signs of shock
Patients with chronic renal failure
Patients with liver disorders
Tracheostomy patients
Patients with presence of use of mechanical ventilatory support;
Patients with physical disabilities; bedridden and wheelchair users.
Patients to withdraw the Consent and Informed
Patients who eventually had to be re-operated in the presence also of the mechanical ventilatory support.

Treatment and study plan

General anesthesia only

Procedure

Induction drugs: Citrate of fentanyl, atracurium, etomidate

General anesthesia and Spinal anesthesia

Procedure

Induction drugs: Citrate of fentanyl, atracurium, etomidate Spinal anesthesia: Bupivacaine hyperbaric, Morphine

Primary outcomes

consumption of fentanyl citrate in intra-operative in Coronary Artery Bypass Grafting surgery with cardiopulmonary bypass under spinal anesthesia associated with general anesthesia.

Time frame: in 24 hours

Will be measure the consumption of fentanyl in 24 hours

Sponsors and collaborators

Lead sponsor

Daniel Gioielli de Castilho

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2015
First posted: Jul 21, 2016
Registry last updated: Jul 21, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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