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NCT Number: NCT07648277

Spinal Alignment, Spinal Mobility, and Balance in Patients With Multiple Sclerosis

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal degeneration. Neuromuscular impairments associated with MS, including muscle weakness, spasticity, fatigue, and proprioceptive deficits, may lead to alterations in spinal posture and reduced spinal mobility. These changes can negatively affect trunk control, balance, respiratory function, and functional independence.

Although postural abnormalities and mobility limitations have been reported in individuals with MS, the relationship between spinal posture, spinal mobility, and balance remains insufficiently investigated. Therefore, this study aims to examine the associations between spinal posture, spinal mobility, and balance performance in individuals with multiple sclerosis. Improved understanding of these relationships may contribute to the development of targeted rehabilitation interventions aimed at enhancing postural control and functional outcomes in this population. This study further hypothesises that alterations in spinal posture and spinal mobility are associated with impaired balance performance in individuals with multiple sclerosis.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Balance Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ankara Yıldırım Beyazıt University

Ankara, Çubuk, 06760, Turkey (Türkiye)

Location status: Recruiting

Location contact

Yasemin Ateş Sarı

CONTACT

[email protected]

05397799535

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of relapsing-remitting multiple sclerosis (RRMS)
  • Aged between 18 and 65 years
  • EDSS score between 0.5 and 4.5
  • Standardized Mini-Mental State Examination score ≥24

Exclusion criteria

  • Receipt of corticosteroid treatment within the previous 4 weeks
  • Presence of any additional neurological disorder
  • Spasticity defined as a Modified Ashworth Scale score ≥3
  • History of surgical intervention involving the lower extremities, spine, or abdominal region

Treatment and study plan

Primary outcomes

  1. Spinal alignment

    Time frame: 1 hour

    Spinal alignment was assessed in the sagittal and frontal planes during neutral standing, maximal trunk flexion, and maximal trunk extension. All spinal alignment parameters were recorded as angular values and expressed in degrees (°).

  2. Spinal mobility

    Time frame: 1 hour

    Spinal mobility was assessed in both the sagittal and frontal planes. In the sagittal plane, mobility was calculated as the angular difference between the neutral standing posture and maximal trunk flexion and extension positions. In the frontal plane, lateral flexion mobility was calculated as the angular difference between the neutral standing posture and maximal right and left lateral flexion positions. All measurements were recorded in degrees (°).

Secondary outcomes

  1. Single-Leg Stance

    Time frame: 1 hour

    Single-leg stance time was recorded in seconds, with shorter durations indicating poorer balance performance.

  2. Time Up and Go

    Time frame: 1 hour

    Dynamic balance was assessed using the Timed Up and Go test. Performance was recorded as the time required to complete the task (seconds), with longer times indicating poorer dynamic balance.

Sponsors and collaborators

Lead sponsor

Ankara Yildirim Beyazıt University

Other

Registry information

Official study title

Relationship Between Spinal Alignment, Spinal Mobility, and Balance in Patients With Multiple Sclerosis

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 15, 2026
Registry last updated
Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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