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Completed

NCT Number: NCT02153710

Speech Therapy for Aphasia: Comparing Two Treatments

This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking. The name of this disorder is called "aphasia." Individuals in this study will receive one of two treatments. The first is a phonological (sound level) treatment and the second is a semantic (word level) treatment. Individuals in both groups will receive 60 hours of therapy for free (2 hours/day, 5 days/week, 6 weeks).

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Key information

Conditions

Stroke Anomia Aphasia Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Communication Disorders Language Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Speech Disorders Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VA Puget Sound Health Care System Seattle Division, Seattle, WA

Seattle, Washington, 98108, United States

About this study

Purpose: The ultimate goal of anomia treatment should be to achieve gains in exemplars trained in the therapy session as well as generalization to untrained exemplars and contexts. Phonomotor treatment (PMT) has shown such effects but has not yet been compared to a commonly used lexical/semantic based treatment (semantic feature analysis; SFA).

Methods: In a between group randomized controlled trial, 58 persons with aphasia characterized by anomia and phonological dysfunction were randomized to receive 56-60 hours of intensively delivered treatment over 6 weeks with testing pre-, post- and three-months post treatment termination.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Single, left-hemisphere stroke
  • English as primary language prior to stroke

Exclusion criteria

  • Other neurological disorders
  • Untreated depression

Treatment and study plan

Semantic Feature Analysis therapy

Behavioral

Control therapy; current standard of care therapy

Phonomotor Therapy

Behavioral

Experimental therapy.

Primary outcomes

  1. Spoken Word Production (Confrontation Naming)

    Time frame: Pretreatment to 3 months following treatment termination change

    Reporting a change in percent correct scores pre-treatment versus 3-months post treatment. (0-100% scale)

Secondary outcomes

  1. Response Latency

    Time frame: Pretreatment to 3 months following treatment termination change

    Change in response latency of confrontation naming pre-treatment versus 3 months post treatment.

  2. Verbs Correctly Named

    Time frame: Pretreatment to 3 months following treatment termination change

    Change in confrontation naming of verbs were scored for accuracy and percent correct (0% to 100%) was analyzed before versus 3 months post treatment.

Sponsors and collaborators

Lead sponsor

VA Office of Research and Development

Fed

Collaborators

  • Portland State University
  • University of Washington

Registry information

Official study title

A Prospective, Controlled Study of Rehabilitation of Anomia in Aphasia

Acronym: PMvSFA

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Jun 3, 2014
Registry last updated
Sep 6, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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