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NCT Number: NCT07173049

Speech Production Enhancement Using Augmentative Communication for Kids

The goal of this clinical trial is to learn if speech supplementation can improve speech intelligibility in children ages 7 to 17 years with cerebral palsy. The main questions it aims to answer are:

* To what extent can speech supplementation improve intelligibility in children with CP compared with habitual speech produced without speech supplementation? * How much intelligibility change is necessary for meaningful improvement when children use speech supplementation strategies?

Participants will:

* complete speech and language assessments * complete a speech pre-test using habitual speech * learn a speech supplementation strategy with training from a speech-language pathologist * complete a speech post-test using the speech supplementation strategy * complete a speech repetition task where specific words are emphasized (emphatic stress) * use the previously learned speech supplementation strategy + emphasis on specific words while producing a set of sentences

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Key information

Age range

7 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Wisconsin-Madison Waisman Center

Madison, Wisconsin, 53705, United States

Location status: Recruiting

About this study

This study uses a pre-/post- test design to test the effects of a one-session intervention to improve speech intelligibility in 100 children with cerebral palsy and dysarthria. The intervention involves the augmentative and alternative communication (AAC) strategy known as speech supplementation. Specifically, children will learn how to simultaneously speak and point to the first letter of each word on a communication board, or to speak and point to a topical picture on a communication board. The strategy serves to provide listeners with context cues for spoken words, and it also serves to impact temporo-acoustic features of speech by reducing rate of speech and making word boundaries clear.

In this study, children will first participate in a set of baseline assessment measures, which will include the production of a corpus of 60 sentences (referred to as "habitual speech"). Then, children will learn to use the speech supplementation strategy through one-on-one clinician modeling, teaching, and practice. When children have mastered the strategy on a set of practice sentences, they will complete a post-test in which they produce the same set of elicited sentences a second time using speech supplementation.

Pre-test and post-test speech samples will then be played to two groups of listeners. One group will orthographically transcribe the words produced by children in both conditions (habitual and supplemented). Listener transcriptions in each condition will be scored as correct or incorrect based on whether they matched the intended word. Average percent of words identified correctly will be obtained from 2 listener for each child and each speaking condition as measures of speech intelligibility. The difference between habitual speech (pre-test) and supplemented speech (post-test) will be examined to quantify the effects of the speech supplementation on intelligibility.

The second set of listeners will hear the same speech samples as the first set (habitual speech and supplemented speech), but they will make ratings of whether one of the conditions seems more understandable than the other, and if so, they will rate how much better using a 7-point Likert scale.

These two sets of data from listeners will enable us to measure the minimum detectable difference in speech intelligibility and then the minimal clinically important difference based on listener ratings. Together these measures will enable us to determine how much change in intelligibility is necessary in order for clinically meaningful improvement.

The hypotheses are as follows:

  • speech supplementation will result in increased speech intelligibility relative to habitual speech.
  • the minimal clinically important difference in intelligibility scores to consider the speech supplementation strategy "successful" will vary depending on child severity, with more severely speech impaired children requiring a larger improvement to achieve a clinically meaningful change.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Medical diagnosis of cerebral palsy, or a similar, related condition that affects early motor development and presents as a chronic motor disability
  • Age between 7 and 17 years
  • Clinical dysarthria with speech intelligibility between 10-85 percent
  • Able to produce connected speech in English, with a minimum utterance length of 3 words
  • Able to use hands to point to items on a communication board
  • Cognitive/language skills that enable basic picture identification on a communication board
  • Pass pure tone hearing screening

Exclusion criteria

  • Failure to meet all inclusion criteria.
  • Vision impairment that precludes being able to see items on a communication board.
  • Not suitable for participation due to other reasons at the discretion of the investigators.

Treatment and study plan

AAC Speech supplementation

Behavioral

The speech supplementation intervention involves learning to point to pictures, words, or letters on a communication board while simultaneously producing speech. Children will spend up to 30 minutes learning to use the strategy in one- on-one interaction with a speech therapist and demonstrate mastery by using the strategy successfully on a series of test stimuli.

Primary outcomes

  1. Change in speech intelligibility scores from pre- to post- intervention as measured by listener transcription of speech samples

    Time frame: Before and after intervention within one session in a single day 1

    Quantify the change in speech intelligibility associated with the use of speech supplementation strategies by having listeners orthographically transcribe speech samples. Intelligibility scores are percentage calculations of the number of words identified correctly by listeners, ranging from 0 to 100 percent. Higher percentages reflect greater intelligibility, or a better understanding of what the speaker said by naive listeners.

Secondary outcomes

  1. Perceived change in intelligibility from pre- to post-intervention as measured by listener ratings of the magnitude of difference between pre- and post- intervention speech samples.

    Time frame: Before and after intervention within one session in a single day 1

    Listener ratings of their perception of the magnitude of change in intelligibility between pre- and post-test speaking conditions. Listeners will hear pre- and post-intervention speech samples and will indicate whether they can hear a differences and if so, how large the differences was using a 5-point likert rating scale. Higher values on the scale reflect larger perceived differences.

Other outcomes

  1. Exploratory: Change in speech rate from pre- to post- intervention as measured by difference in words per minute produced between pre- and post- intervention speech samples

    Time frame: Before and after intervention within one session in a single day 1

    The duration of each utterance produced, inclusive of pauses, will be measured as the total time between the onset of the first word and the offset of the last word. The number of words in each utterance will be divided by the utterance duration, which will be averaged across all utterances pre- intervention and post- intervention at the child level.

  2. Exploratory: Change in intelligibility between pre- and post-speaking conditions for children based on severity of pre-test intelligibility impairment.

    Time frame: Before and after intervention within one session in a single day 1

    Children will be divided into severity groups based on intelligibility scores obtained in pre-test condition. Three severity groups will be operationally defined: mild, moderate, and severe. The investigators will complete analyses of differences in treatment effects for children in the different severity groups to determine if the treatment is more effective for some severity groups than others.

Study contacts

Contact information is provided by the study sponsor or research team.

Heather Mabie

CONTACT

[email protected]

608-263-5822

WISC Lab

CONTACT

[email protected]

608-263-5822

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Collaborators

  • National Institute on Deafness and Other Communication Disorders (NIDCD)

Registry information

Official study title

Speech Supplementation Strategies for Improving Intelligibility in Children With Cerebral Palsy (CP)

Acronym: SPEAK

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Sep 15, 2025
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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