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Completed

NCT Number: NCT05007405

Spectrum of Bacterial Infections in Rheumatology

Retrospective study of patients with a proved non-tuberculous osteoarticular infection (OAI) diagnosed in a rheumatology department during the years 2010-2020. The objectives are :

* To describe sites, type of micro-organism, clinical data, origin of infection, therapeutic modalities et outcome * To compare OAI of urinary origin with those with another origin

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Key information

Conditions

Articular Disease Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Infections Joint Diseases Male Urogenital Diseases Musculoskeletal Diseases Urinary Tract Infections Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Rheumatology, Hospital René Dubos, Pontoise

Pontoise, 95300, France

About this study

This retrospective study will be conducted on medical files. Patients will be mainly selected on :

  • A proved osteoarticular infection (OAI) diagnosed in the department of rheumatology of the René Dubos hospital from 1° January 2010 to 31 December 2020.
  • Adult patients 18 year's old or older
  • Infection proved by positive culture in the osteoarticular site and/or blood (with typical clinical and imaging features)

The followed OAI are not included :

  • Infection on prosthetic joint, materiel ; post-operative OAI ; osteomyelitis
  • Brucellosis ; Lyme disease

Patients are selected from the codification of the hospitalization ; medical files are reviewed by the investigators.

OAI of urinary origin is defined either by the same micro-organism in urine and osteo-articular sample (or blood) or a bacteria in the osteo-articular sample in conjunction with : urologic pathology, recurrent urinary tract infection, urologic surgery, antibiotic therapy.

  • Characteristics of three populations will be compared :
  • - OAI of urinary origin
  • - OAI of another origin (skin, etc)
  • - OAI without known origin Characteristics include : gender, age, risk factors, site of osteo-articular infection, type of micro-organism, type of positive sample(s), blood cultures, urinary cultures, duration of symptoms, site of primary infection and/or type of contamination, biological results, echocardiography, imaging results, type of treatment (medical, surgical), outcome, duration of hospitalization, intensive unit care stay, death at hospital.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subject aged 18 years and over at the time of diagnosis
  • Osteoarticular infection (septic arthritis, spondylodiscitis), by a bacterium or a fungus, proven by a bacteriological sample in situ or in the blood by positive blood culture (with an unequivocal clinical, biological and imaging feature),
  • Diagnosed between 01/01/2010 and 12/31/2020 (11 years)
  • Hospitalization in the rheumatology department of CH René Dubos, Pontoise

Exclusion criteria

  • Bacterial infection due to the following germs: mycobacteria, brucella, Borrelia
  • Early infection on joint prosthesis
  • Peripheral osteomyelitis
  • Osteoarticular infection without bacteriological proof

Treatment and study plan

Groups/Cohortes

Other

Retrospective study on medical file of patients with osteoarticular infections diagnose (date of the positive bacteriological sample) between January 1, 2010 and December 31, 2020

Other names: Osteoarticular infections

Primary outcomes

  1. Identification of the spectrum of osteoarticular infections in adult, in a rheumatology department

    Time frame: Through study completion, an average of 1 year

    The purpose of this database is to describe the spectrum of osteoarticular infections in adults, non-tuberculosis germs, in a rheumatology department of a CHG during the 2010s

Secondary outcomes

  1. Prevalence of urinary origin in osteoarticular infections in adults, compared with other origins

    Time frame: Through study completion, an average of 1 year

    The second purpose of this database is to identify the characteristics of osteo-articular infections of urinary origin

Sponsors and collaborators

Lead sponsor

Hôpital NOVO

Other

Registry information

Official study title

Spectrum of Bacterial Infections in Rheumatology and the Role of Urinary Tract Infection

Acronym: SIBERIE

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Aug 16, 2021
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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