Speckle Plethysmography Pulse Transit Time as a Marker of Blood Pressure Changes

Study Description:

This pilot study will investigate the use of a recently introduced optical technique, speckle plethysmography (SPG), as an alternative to photoplethysmography (PPG) for cuff-free blood pressure (BP) estimation using pulse transit time (PTT). Because of the increased signal quality of SPG in comparison to PPG, we hypothesize that pulse transit times calculated from ECG-SPG (sPTT) will have a better correlation to blood pressure than ECG-PPG (pPTT).

Objectives:

Primary Objective:

To examine the use of sPTT as a marker for blood pressure.

Secondary Objective:

To evaluate the use of sPTT in comparison to pPTT.

Exploratory Objectives:

• To explore if the SPG waveform by itself can be used as a marker for blood pressure.
• To evaluate signal quality of SPG in comparison to PPG across various skin tones.

Endpoints:

Primary Endpoints:

Pearson correlation coefficient between sPTT and BP.

Secondary Endpoints:

Pearson correlation coefficient between pPTT and BP.

Exploratory Endpoints:

• Pearson correlation coefficient between BP and signal markers to be determined.
• PPG Signal-to-noise ratio (SNR), SPG SNR

• INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

• Male or female, aged 18 or greater.
• In good general health as evidenced by medical history and physical.

Exclusion criteria

An individual who meets any of the following criteria will be excluded from participation in this study:

• Any active cardiovascular or pulmonary disorders or use of vasoactive medications.
• History of aneurysm or stroke.
• Pregnant by history.
• History of fainting or seizures.
• An open cut, sore, or bone fracture on or near the hands or feet.
• Known retinopathy, intraocular lens implantation, or glaucoma.
• Any other condition that in the opinion of the investigator would place the participant at unacceptable risk.