Specific Respiratory Infections as Triggers of Acute Medical Events

This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and Hospital Episode Statistics.

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Key information

Conditions

Influenza, Human Adenoviridae Infections Adenovirus Cardiovascular Diseases DNA Virus Infections Human Metapneumovirus Pneumonia Infections Mononegavirales Infections Orthomyxoviridae Infections Parainfluenza Paramyxoviridae Infections Pneumovirus Infections RNA Virus Infections Respiratory Syncytial Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Rhinovirus Virus Diseases

Age range

45 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University College London (UCL)

London, NW1 2DA, United Kingdom

About this study

We will conduct a time series study correlating anonymised population level data on all samples from NHS laboratories testing positive for six common respiratory viruses with admissions to NHS hospitals in England for a range of cardiac and vascular outcomes over the time period 01/01/2004 to 31/12/2014. This will involve generating Poisson regression models controlling for factors such as seasonal and long-term trends, environmental temperature and humidity.

This study is funded by an Academy of Medical Sciences Starter Grant for Clinical Lecturers.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Any individual with a record of an eligible outcome (ICD-10 coded hospitalisation for myocardial infarction or stroke) within the study period aged 45+ years
Any individual with a record of an eligible exposure (laboratory-confirmed respiratory virus) within the study period at any age

Exclusion criteria

Outcome events occurring in people aged <45 years

Treatment and study plan

Primary outcomes

Acute myocardial infarction

Time frame: 01/01/2004 to 31/12/2014

ICD-10 coded
Stroke

Time frame: 01/01/2004 to 31/12/2014

ICD-10 coded

Sponsors and collaborators

Lead sponsor

University College, London

Other

Collaborators

Public Health England

Registry information

Official study title

Specific Respiratory Infections as Triggers of Acute Medical Events: Time Series Analysis Using LabBase and Hospital Episode Statistics

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Dec 6, 2016
Registry last updated: May 4, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed