Skip to main content
OpenTrials
Completed

NCT Number: NCT04141332

Specific Language Impairment (SLI) in Children May Caused by Epileptic Brain Activity

The objective of this study was to find if there is a possible association and the impact of epilepsy and epileptiform activity in children with SLI.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Specific Language Impairment Communication Disorders Language Development Disorders Language Disorders Learning Disabilities Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Specific Language Disorder

Age range

3 year–6 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mansoura University Hospital

Al Mansurah, Dakahlia Governorate, 35516, Egypt

About this study

This study concentrates on the impact of epileptiform activity for childhood epilepsy on the speech and language disturbances in addition to the associated social, cognitive and intellectual dysfunctions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 80 children were suffering from specific language impairment
  • 80 healthy children with age and sex match control group.

Exclusion criteria

  • Previous history of perinatal hypoxic-ischemic damage
  • meningitis or encephalitis
  • motor weakness
  • hearing disorders
  • IQ below seventy
  • CP, social deprivation
  • autism and
  • psychiatric disorders .

Treatment and study plan

EEG was recorded by EEG Machines

Diagnostic Test

EEG was recorded by EEG Machines

Primary outcomes

  1. EEGs finding

    Time frame: 24-48 hours

    EEGs finding were defined according to the followings "Normal: within the range of frequency and amplitude distribution." "Epileptiform: Describes transient background activity with a characteristic spikes, sharp waves, spike-slow wave or sharp-slow wave complexes of focal or generalized distribution".

    "Abnormal non-epileptiform: deviations from normal in terms of background frequency patterns, usually in the form of excessive slow activity".

Other outcomes

  1. Intelligence quotient (IQ)

    Time frame: 24-72 hours

    An intelligence quotient (IQ) is a total score derived from several standardized tests designed to assess human intelligence. Historically, IQ is a score obtained by dividing a person's mental age score, obtained by administering an intelligence test, by the person's chronological age, both expressed in terms of years and months. The resulting fraction is multiplied by 100 to obtain the IQ score.

    When current IQ tests were developed, the median raw score of the norming sample is defined as IQ 100 and scores each standard deviation (SD) up or down are defined as 15 IQ points greater or less.

  2. social age

    Time frame: 24-48 hours

    Evaluation of social age: using the Vineland Social Maturity Scale . VSMS was used along with a cognitive assessment to help make a diagnosis of mental retardation or intellectual disability. It has also been used extensively to assess the development of activities of everyday life.

  3. cognitive age

    Time frame: 24-48 hours

    Evaluation of cognitive age (mental age): using the Stanford Binet Intelligence Scale. The Stanford-Binet test is a examination meant to gauge intelligence through five factors of cognitive ability. These five factors include fluid reasoning, knowledge, quantitative reasoning, visual-spatial processing and working memory. Both verbal and nonverbal responses are measured.

  4. language assessment

    Time frame: 24-72 hours

    Language evaluation: by Comprehensive Arabic Language Test (CALT). The CALT was constructed by the members of the Department of Phoniatrics at Alexandria Main University Hospital, Egypt, to form a detailed comprehensive assessment battery for Arabic language and test its reliability and validity to use it in the early detection of subtle changes in the various components of language in cases of language impaired children.

Sponsors and collaborators

Lead sponsor

Mansoura University Hospital

Other

Registry information

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Oct 28, 2019
Registry last updated
Oct 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.