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NCT Number: NCT03886584

Source Monitoring Déficit in Neuropsychiatric Population

the investigators will measure source-monitoring ability in patients with several neuropsychiatric condition and in healthy controls appaired in age, sex and educational level. Source-monitoring will be measured thanks to internal- and reality-monitoring informatic tasks.The investigators hypothesized patients with fronto-temporal abnormalities would show more marked deficits than patients with only frontal abnormalities.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier Le Vinatier

Bron, Auvergne-Rhône-Alpes, 69678, France

Location status: Recruiting

Location contact

VIAL VERONIQUE

CONTACT

[email protected]

0033437915531

About this study

Source-monitoring abilities will be measured thanks to reality-monitoring testing (i.e. the ability to distinguish internal-generated events from external ones) and internal-monitoring testing (i.e. the ability to distinguish an imagined source from a performed one). A source-monitoring deficit have been demonstrated in patients with psychiatric conditions such as schizophrenia and seems linked to frontotemporal abnormalities (frontotemporal dysconnectivity and temporal hypoactivity). With a total of 150 patients, the investigators will include 30 patients per group: patients with pre-dementia stage Alzheimer, Alzheimer, Fronto-Temporal dementia, Lewy Body dementia or Parkinson and Bipolar Disorder, with the hypothesis that Bipolar Disorder patients will present less marked deficit. The investigators will recruit 150 healthy controls.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects who gave their free and informed consent;
  • Men and women;
  • Aged 18 to 80;
  • Having normal or corrected vision;
  • Mastering the French language (read and spoken);
  • All subjects will not have a working memory deficit preventing the test from being passed (MMSE short version):AM patients should have a score of <MMSE <26; Patients with pre-dementia AD will be diagnosed according to Dubois criteria (Dubois et al., 2016); patients with early FTD will be diagnosed according to Rascovsky's criteria (Rascovsky et al., 2011); Patients with DCL will be diagnosed according to McKeith's criteria (McKeith et al., 2005), TBP patients will be diagnosed using DSM 5 criteria (Arlington VA, 2013).

Exclusion criteria

  • Inadmissibility of the consent or refusal of the subject.
  • Patients under guardianship

Treatment and study plan

Monitoring source test

Other

Internal- and external-monitoring correct responses and inversions

Primary outcomes

  1. measure source memory performance

    Time frame: one year

    in patients with neuropsychiatric disorders with or without temporal involvement (pre-dementia Alzheimer's disease, Alzheimer's disease - AD, fronto-temporal dementia - DFT, Lewy body dementia - DCL and bipolar disorder - TBP) and healthy volunteers matched in age, gender, and level of education.

Secondary outcomes

  1. measure the recognition of distractors

    Time frame: one year

    words not presented during the source monitoring test phase but presented during the recall phase. This measure will allow us to avoid that a disturbance invading the working memory or attentional capacities does not compromise the good realization of the task.

Study contacts

Contact information is provided by the study sponsor or research team.

JEROME BRUNELIN, PHD

CONTACT

[email protected]

00334 37 91 55 65

Jean-Michel DOREY, PHD

CONTACT

[email protected]

00334 37 91 52 49

Sponsors and collaborators

Lead sponsor

Hôpital le Vinatier

Other

Registry information

Important dates

Study start
2019
Primary completion
2026
Study completion
2026
First posted
Mar 22, 2019
Registry last updated
Jul 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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