Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass

More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass. However, the incidence of postoperative acute lung injury due to cardiopulmonary bypass is still as high as 20% to 35%. According to clinical experience, the earlier lung damage is detected, the more successful the treatment will be. On the basis of traditional detection, the investigators found a new indicator, serum soluble vascular endothelial-cadherin, which are easy to obtain and have certain specificity. Importantly, they can predict postoperative acute lung injury within 1 hour after cardiac surgery. It is meaningful that this indicator can provide clinicians with early decision-making advice and immediate treatment for patients who may be at risk.

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Key information

Conditions

Hypoxemia ARDS Acute Lung Injury Cardiopulmonary Bypass Hypoxia Lung Diseases Lung Injury Lung Injury, Acute Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

the Affiliated Hospital of Yangzhou University

Yangzhou, Jiangsu, 225000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years;
Underwent cardiac surgery using CPB technology.

Exclusion criteria

Patient's lack of consent to participate;
Presence of abnormal liver, kidney or other organ function;
Pulmonary inflammation, chronic obstructive pulmonary disease or tumors;
Underwent cardiac surgery without CPB technology;
Postoperative need for extracorporeal membrane oxygenation support.

Treatment and study plan

blood cell analysis, blood gas surveillance, chest radiograph and echocardiography

Diagnostic Test

Laboratory parameters of all postoperative patients including blood cell analysis, blood gas surveillance, liver, and kidney function alone with chest radiograph and echocardiography were dynamically monitored.

Primary outcomes

PaO2/FiO2 ratio

Time frame: Day 1 after CPB, Day 2 after CPB

The ratio of inspiratory oxygen fraction to oxygen pressure (PaO2/FiO2) was calculated
lung-injury scores

Time frame: Day 1 after CPB, Day 2 after CPB

A structured tutorial was used to establish consensus in the interpretation of radiographs for radiographic lung-injury scores, range from 0 to 4.

0: No alveolar consolidation; 1: Alveolar consolidation confined to 1 quadrant; 2: Alveolar consolidation confined to 2 quadrants 3: Alveolar consolidation confined to 3 quadrants; 4: Alveolar consolidation in all 4 quadrants.

The higher scores mean a worse outcome.

Sponsors and collaborators

Lead sponsor

Zhuan Zhang

Other

Registry information

Official study title

Soluble Vascular Endothelial-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2022
First posted: Dec 12, 2022
Registry last updated: Dec 12, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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