Soluble VE-cadherin and VE-cadherin Antibody in Sclerodermic Sclerosis

Ve-cadherin is expressed in endothelial cells. Systemic slerosis is a rare auto-immune disease with a endothelial dysfunction. This study is to evaluated the level of soluble VE-cadherin and VE-cadherin antibody in patients with systemic slerosis.

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Key information

Conditions

Primary Raynaud Disease Connective Tissue Diseases Scleroderma, Systemic Skin Diseases Skin and Connective Tissue Diseases Systemic Sclerosis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Grenoble University Hospital

Grenoble, 38043, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

group 1: systemic sclerosis
group 2: raynaud primary disease

Treatment and study plan

soluble Ve cadherin

Biological

dosage of soluble VE cadherine in each arms

Primary outcomes

Level of soluble Ve-cadherin and antibody VE-cadherin with ELISA TEST in Scleroderma group versus Primary Raynaud's Phenomenon

Time frame: At 30 days average

Level of human sVE and antibody VE-cadherin in blood will be determined by ELISA test in both groups Scleroderma and Primary Raynaud's Phenomenon.

The methodology of dosage of sVE is based on the pattern:WO/2008/062314 The methodolody of the dosage of antibody VE-cadherin is based on the pattern WO/2012/136820 .

Group Scleroderma (N=60) versus Primary Raynaud's Phenomenon (N=20). Shapiro test.

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Acronym: Sclerocadh1

Important dates

Study start: 2014
Primary completion: 2016
Study completion: 2016
First posted: Aug 8, 2014
Registry last updated: Mar 24, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed