Sodium Intake in Multiple Sclerosis

Recently, it has been shown that salt (ClNa, sodium chloride) can modulate the differentiation of human and mouse TH17 cells. Indeed, mice feed with high sodium diet were described to develop more aggressive course of EAE (Experimental Autoimmune Encephalitis).

However, the role of sodium intake in MS has not been investigated. In this study we investigate the effect of sodium intake in Multiple Sclerosis (MS) clinical and radiological activity.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

FLENI

Buenos Aires, 1428, Argentina

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subject is between 18 and 50 years old
Subject has diagnosis of relapsing-remitting MS according to McDonald criteria (2010)

Exclusion criteria

Patient who had hyponatremia in the last 90 days

Treatment and study plan

Primary outcomes

Exacerbation rate

Time frame: 2 years

Number of disease relapses during follow up time according to salt consumption

Secondary outcomes

Radiological activity

Time frame: One year

Number of new lesions in MRI

Sponsors and collaborators

Lead sponsor

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Other

Registry information

Official study title

Effect of Sodium Intake in Multiple Sclerosis Disease Activity

Acronym: SALT

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2013
First posted: May 3, 2013
Registry last updated: Oct 22, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed