CES1 Carriers in the PAPI Study
NCT03188705
Arterial Occlusive Diseases, Arteriosclerosis
Lancaster, Pennsylvania, United States
View Trial DetailsNCT Number: NCT00005522
To examine biopsychosocial processes that might contribute to the associations among social dominance, gender, and cardiovascular reactivity,.
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Notify MeUp to 100 year
All sexes
Observational
BACKGROUND:
Social dominance, the tendency to exercise social influence and control, has been positively associated with coronary heart disease (CHD) risk among males, independent of biomedical risk factors and hostility. Exposure to dominant others behaviors also has been associated with elevated CHD risk. For females, submissiveness and a constellation of psychosocial behaviors opposite to urgency and competitiveness have been associated with increased risk for cardiovascular disease (CVD). The studies extend a growing literature concerning the central role of social relationships in health and illness and they test a theoretical model that addresses why social relationships and interpersonally-oriented person variables such as dominance may have differing consequences for the physical well-being of men and women.
DESIGN NARRATIVE:
The three studies were designed to test a social-contextual model of dominance and cardiovascular stress reactivity (CVR) that synthesized and elaborated earlier models in order to account for (1) cardiovascular consequences of exposure to dominant others and (2) differences in dominant men's and women's cardiovascular responses to social interactions. Because of the disproportionately high rates of CVD among Black Americans, both Black and white men and women were included in the studies.
Using a laboratory social interaction paradigm, study 1 refined and validated a coding system designed to assess dominant and hostile behaviors during dyadic social interaction. Study 2 examined two factors proposed to account for differences in dominant men's and women's cardiovascular responses to social interaction: (1) explicit role demands regarding dominance expression (i.e., the degree to which situations provided clear and salient cues regarding expected and acceptable behavior) and (2) gender composition of the dyad (i.e., same sex versus opposite sex). These two factors were manipulated independently while unacquainted, healthy young adult men and women participated in task-oriented dyadic discussions designed to activate motives to influence; cardiovascular responses were measured during the discussions and preceding rests. Study 3, a secondary analysis of data collected in study 2, examined associations between CVR and exposure to others' dominance. The aforementioned behavioral coding system was used to assess behavioral dominance observed in study 2 and path analytic techniques were used to model associations among CVR, one's own and one's partner's trait and behavioral dominance, gender, and situational factors.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
No eligibility criteria
National Heart, Lung, and Blood Institute (NHLBI)
Nih
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