Sleepiness and Brain Function: The Effect of Armodafinil in Shift Work Sleep Disorder

The investigators hypothesize that in patients with shift work sleep disorder, armodafinil will specifically increase brain activity in the frontal cortex parallel with improvements in deficits of fundamental mechanisms of attention.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Shift Work Sleep Disorder Chronobiology Disorders Dyssomnias Mental Disorders Nervous System Diseases Occupational Diseases Sleep Disorders, Circadian Rhythm Sleep Wake Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Henry Ford Hospital Sleep Disorders & Research Center

Detroit, Michigan, 48202, United States

About this study

The current protocol will utilize a paradigm which is well suited to examine frontal attentional neuronal mechanisms by eliciting event related potential components known to reflect automatic stimulus detection as well as involuntary and voluntary attentional processes. The that end the proposed research has two specific aims. 1) Identify what areas of the frontal lobe and corresponding cognitive functions are impacted by excessive sleepiness in shift work sleep disorder and 2) identify specific brain areas affected by armodafinil and their role in improvement of fundamental attentional processes using a complex cognitive task targeting attentional control.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Night shift workers with and without shift work sleep disorder.

Exclusion criteria

Secondary condition to shift work sleep disorder.

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Collaborators

Cephalon

Registry information

Official study title

Magnetoencephalographic Imaging of Sleepiness: The Effect of Armodafinil in Shift Work Sleep Disorder

Important dates

Study start: 2008
Primary completion: 2010
Study completion: 2010
First posted: Jun 2, 2008
Registry last updated: Mar 31, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed