neuropsychological testing
Behavioralmemory, executive testing, behaviour questionnaire, visual attention,
NCT Number: NCT03865771
Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information.
Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group.
Primary purpose:
To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group.
Secondary purposes:
* to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture
Interested in participating?
Request Info6 year–13 year
All sexes
Interventional
Not applicable
Hopital D'Enfants Pediatrie Medicale Ambulatoire, Nancy, France
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Principal:
Specific
Patients from "severe" and "benign" groups:
Control group
-children hospitalized for a non neurologic disease
Exclusion criteria
Principal:
Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care
Specific
Patients from "severe" and "benign" groups:
Control group
memory, executive testing, behaviour questionnaire, visual attention,
Rey auditory verbal learning test, Delayed recall : 1h, 5h, 24h (after one night sleep)
Video EEG : 10 electrodes + 3 electrodes for PSG 2h wake EEG Whole night EEG
Time frame: 24 hours
Time frame: at 1 hour, 5 hours, 24 hours
Time frame: at 1 hour, 5 hours, 24 hours
Time frame: at 1 hour, 5 hours, 24 hours
Time frame: at 1 hour, 5 hours, 24 hours
Time frame: at 1 hour, 5 hours, 24 hours
Contact information is provided by the study sponsor or research team.
Anne DE SAINT MARTIN, MD
CONTACT
Lucille SCHNEIDER
CONTACT
University Hospital, Strasbourg, France
Other
Acronym: EPIMEM
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT07563881
Brain Diseases, Central Nervous System Diseases
Palmdale, California, United States
View Trial DetailsNCT00060541
Basal Ganglia Diseases, Brain Diseases
Bethesda, Maryland, United States
View Trial DetailsNCT02107989
Brain Diseases, Central Nervous System Diseases
Bethesda, Maryland, United States
View Trial DetailsNCT06660394
Brain Diseases, Central Nervous System Diseases
Little Rock, Arkansas, United States
View Trial Details