Sleep Disturbances as a Non-traditional Risk Factor in CKD-Actigraphy

To test if usual at home night time sleep duration as measured with activity monitors and questionnaires will predict changes in kidney function as measured by kidney filtration rate and of cardiovascular function as measured by C-reactive protein in the blood. The study will explore the role of decreased sleep time or decreased sleep quality as a non-traditional risk factor for the progression of CKD and for the development of cardiovascular disease in CKD.

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Key information

Conditions

Chronic Kidney Disease Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Sleep Loss Urogenital Diseases Urologic Diseases

Age range

21 year–74 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The University of Chicago

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Mild to Moderate CKD
Healthy controls age and gender matched to CKD subjects
Regular bedtimes of at least 6h/night, sedentary lifestyle

Exclusion criteria

Diabetes
Current or previous dialysis for more than 1 month
Uncontrolled hypertension
Heart failure
Liver disease
HIV
Hemoglobin < 10.5 g/dl
Treatment with EProcrit, Epogen, or Aranesp
Bone or organ transplant,
Use of immunosuppressive drugs within past 6 months
Current oral contraceptive use
Current pregnancy
Chemotherapy for malignancy within past 2 years

Treatment and study plan

Primary outcomes

CKD progression as measured by changes in GFR and cardiovascular risk as measured by CRP over a 5 year period

Time frame: 5 years

Secondary outcomes

insulin resistance

Time frame: 5 years

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

Case Western Reserve University
University of Illinois at Chicago

Registry information

Official study title

Sleep Disturbances as a Non-traditional Risk Factor in CKD-Wrist Actigraphy

Acronym: CRIC

Important dates

Study start: 2007
Primary completion: 2010
Study completion: 2010
First posted: Jan 6, 2009
Registry last updated: Sep 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed