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OpenTrials
Completed

NCT Number: NCT02457000

Sleep, Circadian Rhythm & Skin Health

The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.

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Key information

Conditions

Healthy Acne Acne Vulgaris Acneiform Eruptions Dermatitis Eczema Psoriasis Sebaceous Gland Diseases Skin Diseases Skin Diseases, Eczematous Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44118, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males or females ages 18 years and above
  • Capable of giving informed consent
  • Adults who are either healthy, normal volunteers or those with a skin disease including but not limited to eczema, psoriasis, acne or other inflammatory dermatoses
  • Fitzpatrick Skin Type I-VI
  • In good general health
  • Willing to cooperate with study instructions

Exclusion criteria

  • Volunteers 18 years or younger
  • Any serious medical or physical condition that would cause the subject significant discomfort with study procedures
  • Women who are pregnant, nursing, or who may become pregnant in the next 3 months

Treatment and study plan

Primary outcomes

  1. Analysis of Sleep Pattern via Actigraphy, Polysomnography & Questionnaires

    Time frame: 7-14 days

    The volunteers may be asked to wear a wrist actigraph to measure movement. This watch would be worn for 24 hours per day for 7-14 days. The volunteer may also be asked to fill out questionnaires regarding their sleep patterns. Note: Other methods of assessing sleep patterns may also be used including a portable polysomnogram or a standard, overnight sleep study.

  2. Evaluation of skin (both in terms of skin aging and skin disease)

    Time frame: Only once during the study or at specific time points depending on what other procedures are being performed

    The volunteers may have their skin evaluated for skin aging using the SCINEXA tool. Volunteers with psoriasis may have their skin evaluated via PASI and/or PGA assessments. Volunteers may have photographs taken to compare clinical appearance with laboratory and research findings.

Secondary outcomes

  1. Sample Analysis (from skin, blood, urine, saliva and hair follicle samples)

    Time frame: Only once during the study or at specific time points depending on what other procedures are being performed

    Skin, blood, urine, saliva and hair follicle samples may be collected from some volunteers to look at various markers related to sleep, the circadian rhythm and skin disease.

  2. Skin Barrier Recovery (via TEWL measurement)

    Time frame: Only once during the study or at specific time points depending on what other procedures are being performed

    Skin barrier recovery via Transepidermal Water Loss (TEWL) measurement may be assessed in some volunteers.

  3. MED Testing & Recovery from UV-induced erythema

    Time frame: 24 hours

    MED Testing & Recovery from UV-induced erythema may be assessed in some volunteers.

Sponsors and collaborators

Lead sponsor

University Hospitals Cleveland Medical Center

Other

Registry information

Important dates

Study start
2015
Primary completion
2020
Study completion
2020
First posted
May 29, 2015
Registry last updated
Dec 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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