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Completed

NCT Number: NCT01130948

Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects

This study investigates the effect of altitude exposure on sleep, breathing and psychomotor performance in healthy subjects.

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Key information

Conditions

Healthy Men Apnea Dyssomnias Hypoxia Nervous System Diseases Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory Sleep Apnea Syndromes Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year–70 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital of Zurich, Pulmonary Division

Zurich, CH-8091, Switzerland

About this study

Sleep is essential for well being and performance. Sleep disturbances by recurrent apnea and hypoxia in patients with obstructive sleep apnea syndrome impair quality of life, cognitive and cardiovascular functions. Similar consequences occur in healthy subjects exposed to hypoxia at altitude due to periodic breathing with recurrent central apnea. This project will investigate effects of altitude on sleep, breathing, psychomotor performance and on the cardiovascular system in healthy subjects and patients with sleep apnea. The results will help to better understand mechanisms of sleep disturbances and psychomotor impairment induced by hypoxia and to prevent adverse effects of altitude exposure.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy men
  • residence at <800m

Exclusion criteria

  • any active disease requiring treatment
  • requirement for regular use of medication
  • smoking, regular intake of alcohol or drugs
  • body mass index <18 or >30 kg/m2
  • previous intolerance of moderate altitude (<3000m)

Treatment and study plan

Altitude exposure

Other

exposure to 490m, 1700m and 2590m

Primary outcomes

  1. apnea/hypopnea index

    Time frame: day 1-4 at altitude

  2. Reaction time

    Time frame: day 1-4 at altitude

    psychomotor vigilance test reaction time

Secondary outcomes

  1. Psychomotor vigilance

    Time frame: day 1-4 at altitude

    performance in the Motor Task Manager test

  2. sleep quality

    Time frame: day 1-4 at altitude

    percent of slow wave sleep, araousal index

  3. arterial applanation tonometry

    Time frame: day 1-4 at altitude

    endothelial function and arterial stiffness

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
May 26, 2010
Registry last updated
May 20, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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