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Completed

NCT Number: NCT03130322

SLeep and IMagery Correlates (SOMMEIL-IMAGERIE)

This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.

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Key information

Conditions

Healthy

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CH le Vinatier

Bron, 69500, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy right-handed persons without neurologic disease
  • Persons having signed informed consent for a neuroimagery study

Exclusion criteria

  • Persons under curatorship or any administrative/judicial measure
  • Participants refusing to be informed of the results of the experiment
  • Pregnant women
  • Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth.
  • Persons using a pacemaker, insulin pump, or working regularly with iron filings
  • Claustrophobic persons

Treatment and study plan

Imagery and Sleep questionnaires

Other

Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep

MEG recordings (pre-test)

Other

Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h).

Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.

Practice session

Other

Participants of the Day group perform a block of motor imagery practice of the two motor tasks.

MEG recordings (Post-test)

Other

Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test)

MRI

Other

The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.

Primary outcomes

  1. Evidence of MEG correlates of sleep motor consolidation (day 1)

    Time frame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)

    The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.

  2. Evidence of MEG correlates of sleep motor consolidation (day 2)

    Time frame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

    The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.

Secondary outcomes

  1. Time needed to complete the motor tasks (day 1)

    Time frame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)

    The investigators will measure the time needed to complete the motor tasks needed to complete each motor task (finger sequential tasks OR motor adaptation task).

  2. Evidence of MEG correlates of sleep motor consolidation

    Time frame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

    The investigators will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.

  3. Accuracy of the motor tasks

    Time frame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)

    The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).

  4. Time needed to complete the motor tasks

    Time frame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

    The investigators will measure the time needed to complete each motor task (finger sequential tasks OR motor adaptation task).

  5. Accuracy of the motor tasks 2

    Time frame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

    The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Neurophysiological Correlates of Sleep Motor Consolidation Following Motor Imagery Practice

Important dates

Study start
2015
Primary completion
2017
Study completion
2018
First posted
Apr 26, 2017
Registry last updated
Sep 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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