Skip to main content
OpenTrials
Completed

NCT Number: NCT01248377

Skin Testing and ELISPOT Assay in Patients With a History of Non-Immediate Reactions to Cephalosporins

This study aims to compare the results of skin testing and ELISPOT assay in patients with a history of non-immediate reactions to cephalosporins

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cephalosporin Allergy Chemically-Induced Disorders Drug Hypersensitivity Drug-Related Side Effects and Adverse Reactions Non-immediate Drug Reactions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Medicine, Chulalongkorn University

Bangkok, 10330, Thailand

About this study

Patients with a history of non-immediate reactions to cephalosporins will be tested by patch test and/or intradermal test. Peripheral blood mononuclear cells will be collected to analyzed cytokine secretions by ELISPOT assay

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a history of non-immediate hypersensitivity reactions to cephalosporins
  • At least 18 years of age

Exclusion criteria

  • Suffering from severe systemic disease/ in bad health
  • Being pregnant
  • Patients with a history of immediate reactions to cephalosporin

Treatment and study plan

Skin tests and ELISPOT assay

Procedure

Patch test and/or intradermal test will be performed in patients as well as cytokine secretions from PBMCs will be analyzed by ELISPOT assay

Other names: Patch test, Intradermal test, ELISPOT

Primary outcomes

  1. The skin testing results of Cephalosporin skin test compared to ELISPOT assay

    Time frame: 1 year

Secondary outcomes

  1. The result of cross reactivity between Cephalosporins and other Betalactams determined by skin testing and ELISPOT assay

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Chulalongkorn University

Other

Registry information

Official study title

The Results of Skin Testing and The Detection of Cytokine Secretion From Drug Specific Peripheral Blood Mononuclear Cells Using ELISPOT Assay in the Diagnosis of Nonimmediate Reactions to Cephalosporins

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Nov 25, 2010
Registry last updated
Oct 12, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.