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Completed

NCT Number: NCT01719133

Skin Prick Tests With AllerT in Subjects Allergic to Birch Pollen

Assessment of skin reactivity by skin prick tests to synthetic peptides derived from the major birch allergen bet v 1, in subjects allergic to birch pollen.

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Key information

Conditions

Allergic Rhinitis Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Nose Diseases Otorhinolaryngologic Diseases Respiratory Hypersensitivity Respiratory Tract Diseases Rhinitis Rhinitis, Allergic

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Centre Hospitalier Universitaire Vaudois

Lausanne, Switzerland

About this study

The study tested - all by skin tests - in the same group of 20 trial subjects, one positive control (histamine solution), one negative control (placebo saline) and five experimental peptides called T1, T2, T3, T4 and T5. Results of the skin prick tests were scored as negative (no reaction) or positive (wheal diameter > 4 mm with erythema)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • history of allergy symptoms during previous birch pollen season
  • positive skin prick test to birch pollen extract

Exclusion criteria

  • pregnancy
  • uncontrolled asthma
  • other significant clinical conditions or immune disorders
  • subjects taking antihistamines or drugs with antihistamine activity

Treatment and study plan

Placebo

Drug

saline solution

Other names: saline

Histamine

Drug

positive control

Other names: Histamine solution

AllerT1

Drug

synthetic peptide T1

AllerT2

Drug

synthetic peptide T2

AllerT3

Drug

synthetic peptide T3

AllerT4

Drug

synthetic peptide T4

AllerT5

Drug

synthetic peptide T5

mix of AllerT1-T2-T3

Drug

mix of peptides T1, T2 and T3

Other names: AllerT

mix of AllerT4-T5

Drug

mix T4-T5

Other names: mix T4-T5

Primary outcomes

  1. skin prick test reactivity

    Time frame: 15 minutes

Sponsors and collaborators

Lead sponsor

Anergis

Industry

Registry information

Official study title

Détermination de la réactivité cutanée de Volontaires Allergiques au Pollen de Bouleau Contre Des Peptides dérivés de Bet v 1

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Nov 1, 2012
Registry last updated
Nov 1, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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