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NCT Number: NCT07700186

Skin Barrier Function in Women Using UV Nail Lamps

The goal of this observational study is to compare objective parameters of skin barrier function between healthy adult women who regularly use UV lamps during nail treatments and women who do not use UV lamps.

The main questions it aims to answer are:

* Do women who regularly use UV lamps for nail treatments show differences in skin barrier function compared to women who do not use UV lamps? * Are transepidermal water loss, skin hydration, and erythema associated with regular exposure to UV lamps used for nail treatments? * Does the duration of UV lamp use influence skin barrier function parameters?

Researchers will compare women who regularly use UV lamps during nail treatments with women who have natural nails and do not regularly expose their hands to UV lamps.

Participants will:

* Attend a single study visit. * Complete a short questionnaire regarding nail care habits and duration of UV lamp use. * Undergo non-invasive measurements of skin barrier function on the hands, including transepidermal water loss, skin hydration, and erythema assessments.

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Key information

Conditions

Healthy Volunteers Erythema Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Diseases Skin Manifestations Skin and Connective Tissue Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

University of Split School of Medicine

Split, 2100, Croatia

Location status: Recruiting

Location contact

Josipa Bukić

CONTACT

[email protected]

+385917933753

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adult women (≥18 years of age)
  • Willing and able to provide written informed consent
  • Willing to complete the study questionnaire

Exclusion criteria

  • Active skin diseases (e.g., psoriasis, vitiligo, or other dermatological conditions)
  • Allergic contact dermatitis
  • Pregnancy or breastfeeding
  • Use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines

Treatment and study plan

Primary outcomes

  1. Change in Transepidermal Water Loss (TEWL)

    Time frame: Day 1 (single study visit)

    Skin barrier function will be assessed by measuring transepidermal water loss using a Tewameter TM 300 probe. Values will be expressed in g/m²/h

  2. Change in Skin Hydration

    Time frame: Day 1 (single study visit)

    Hydration of the stratum corneum will be assessed using a Corneometer CM 825 probe.

  3. Change in Skin Erythema

    Time frame: Day 1 (single study visit)

    Skin erythema will be assessed using a Mexameter MX 18 probe.

Study contacts

Contact information is provided by the study sponsor or research team.

Josipa Bukić

CONTACT

[email protected]

+385917933753

Sponsors and collaborators

Lead sponsor

University of Split, School of Medicine

Other

Registry information

Official study title

Comparison of Objective Skin Barrier Function Parameters Between Women Who Use and Women Who Do Not Use UV Nail Lamps for Nail Treatments

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 13, 2026
Registry last updated
Jul 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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