Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin

The goal of this study is to compare how the appearance of dry skin changes before and after the use of following moisturizers: white petrolatum, coconut oil, jojoba oil and almond oil). Up to 40 subjects from Banner-University Medical Center/University of Arizona dermatology clinics and University of California, Davis dermatology clinics (up to 20 subjects per site) who have dry skin will be enrolled in this study and randomized to receive the four moisturizers on four locations on their forearms.There will be a total of 3 study sessions: baseline, and approximately 1 and 2 weeks for follow up assessment. At each visit, dry skin severity will be evaluated by a trained observer using a validated Dry Skin Score, skin barrier biophysical properties (transepidermal water loss and hydration) will be measured, and digital photos of the test sites will be taken for image analysis.

Inclusion criteria

• Male and female, at least 18 years of age
• Subject must receive a diagnosis of dry skin by a dermatologist.
• Subject must be able to comprehend and read the English language.

Exclusion criteria

• Subjects who do not fit the inclusion criteria.
• Subjects unable to or unwilling to comply with the study procedures
• Prior known allergy to white petrolatum, coconut oil, almond oil, or jojoba oil.
• People who have used products containing white petrolatum, jojoba oil, coconut oil, or almond oil within the past week.
• People with a known diagnosis of ichthyosis.
• A subject who, in the opinion of the investigator, will be un-cooperative or unable to comply with study procedures.
• Subject unable to speak or read the English language, since all consents and instructions will be provided in English.
• Those that are prisoners or cognitively impaired