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OpenTrials
Completed

NCT Number: NCT03146286

Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions

The aim of the study will investigate whether impairment in the action of insulin to promote the use of glucose in skeletal muscle (insulin resistance) as a result of oral ingestion of a liquid meal rich in saturated fat is linked to reduced ability of muscles to synthesise new protein in response to dietary protein intake, which ultimately may compromise maintenance of muscle size and quality of life and whether partially replacing saturated fat in the liquid meal with omega 3 polyunsaturated FA (n3PUFA) will ameliorate these negative effects.

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Key information

Conditions

Insulin Resistance Glucose Metabolism Disorders Hyperinsulinism Metabolic Diseases Nutritional and Metabolic Diseases

Age range

40 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male, healthy, overweight (BMI>27 kg/m2 and fat mass >30%) non-diabetic individuals.

Exclusion criteria

  • Diabetes, smoking, cardiovascular disease

Treatment and study plan

Saturated fat

Dietary Supplement

Palm stearin

Placebo

Dietary Supplement

Water

Fish Oil

Dietary Supplement

Fish Oil, Omega 3 PUFA

Primary outcomes

  1. Change in muscle protein fractional synthetic rate

    Time frame: 3 hours post protein drink

    Measurement of FSR at baseline and post intervention

Secondary outcomes

  1. whole body postprandial insulin sensitivity

    Time frame: Baseline and every 15mins for 7 hours

    Glucose and insulin area under the curves (AUC) in response to the milk protein and glucose ingestion will be measured

  2. Whole body and skeletal muscle fat oxidation

    Time frame: Baseline and every 15mins for 7 hours

    D31palmitate plasma enrichment and incorporation into skeletal muscle lipids

Sponsors and collaborators

Lead sponsor

University of Nottingham

Other

Registry information

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
May 9, 2017
Registry last updated
May 21, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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