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Completed

NCT Number: NCT03027479

Skeletal Muscle Energy Metabolism in Women With Weight Loss and Ovarian and/or Endometrial Cancer With Weight Loss

the aim is to study skeletal muscle metabolism alterations métaboliques associated with weight loss in women with ovarian and/or endometrial cancer according to BMI.

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Key information

Conditions

Weight Loss Adnexal Diseases Body Weight Body Weight Changes Endocrine Gland Neoplasms Endocrine System Diseases Endometrial Carcinoma Endometrial Neoplasms Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Gonadal Disorders Neoplasms Neoplasms by Site Nutrition Disorders Nutritional and Metabolic Diseases Obesity Ovarian Carcinoma Ovarian Diseases Ovarian Neoplasms Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Urogenital Diseases Urogenital Neoplasms Uterine Diseases Uterine Neoplasms

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Gynecology Department, University Teaching Hospital, Tours

Tours, 37044, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Case group selection criteria:

Inclusion criteria

  • Women aged 18 years old and more
  • Ovarian and/or endometrial cancer
  • weight loss related to cancer (weight loss > 5% weight in one month or 10% in 6 months)
  • Indication to therapeutic surgery
  • Women affiliated to social security scheme
  • Women who can understand French and able to sign Informed consent

Exclusion criteria

  • Unbalanced Diabetes
  • Chronic neuromuscular disorder
  • Any severe uncontrolled medical condition

Control group selection criteria:

Inclusion criteria

  • Women aged 18 years and more
  • Surgery Indication for a benign endometrial and/ or ovarian disease
  • Patient affiliated to social security scheme
  • Women who can understand French and able to sign Informed consent

Exclusion criteria

  • Unbalanced Diabetes
  • Chronic neuromuscular disorder
  • Any severe uncontrolled medical condition

Treatment and study plan

Samples

Other

Blood samples, muscle biopsy, adipose tissue samples and ovarian cancer tumor sample

Primary outcomes

  1. Measurement of muscle mitochondrial bioenergetics according to BMI

    Time frame: muscle biopsy realized during surgery

    Measurement of muscle mitochondrial bioenergetics by high resolution oxygraphy

Secondary outcomes

  1. on muscle biopsy

    Time frame: muscle biopsy realized during surgery

    • Quantification of lipids on electron microscope
    • Type of muscular fibers
    • Analyze of gene expression and proteins involved in 1/ Mitochondrial metabolism 2/ lipid metabolism and 3/ muscular proteolysis by RTqPCR with SyBR Green and Western Blot

  2. on white adipose tissue

    Time frame: adipose tissue samples taken during surgery

    adipose tissue composition (fatty acids quantification, sterols, steroids)

    • RT-qPCR quantification of molecules involved in lipid metabolism (synthesis, transport) and in inflammation (immune profile and cytokines)
    • RTqPCR analysis, western blot and immunohistochemical expression of markers of transformation into brown adipose tissue
    • in specific milieu, in vitro experimentation on skeletal muscular cells

  3. on ovarian cancer tumor samples

    Time frame: ovarian tumor biopsies realized during surgery

    • lipid composition (fatty acids quantification, sterols, steroids)
    • RT-qPCR quantification of molecules involved in lipid metabolism (synthesis, transport) and in inflammation (immune profil and cytokines)
    • culture of tumour cells to evaluate resistance to chemotherapy (platinum)

  4. on computerized tomography

    Time frame: 1 day of abdominal CT scan imaging procedure performed at diagnosis

    assessment of body composition (fat and muscle compartments)

Sponsors and collaborators

Lead sponsor

University Hospital, Tours

Other

Collaborators

  • Inserm U1069 - Team Nutrition, Growth and Cancer

Registry information

Official study title

Study of Differences in Skeletal Muscle Energy Metabolism Alterations in Women With Weight Loss and Ovarian and/or Endometrial Cancer Based on the Body Mass Index

Acronym: METERMUS-IMC

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Jan 23, 2017
Registry last updated
Dec 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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