Skip to main content
OpenTrials
Completed

NCT Number: NCT07354373

Single-Visit and Two-Visit Endodontic Treatments

You are being asked to participate in this research study because you are being treated at the UCSF Graduate Endodontics department for an endodontic procedure. We are trying to determine the treatment outcomes of one v. two-visit endodontic treatments. .If you decide to continue, we would like to request your consent for a follow up period of 1 year to observe the healing of the abscess. Observation periods occur at 6 months following the completion of the root canal and at 12 months and are a part of the standard of care. We will review findings in the Axium chart, which will be recorded by the treating doctor

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of California San Francisco School of dentistry

San Francisco, California, 94143, United States

About this study

This research study includes patients who are receiving endodontic treatment within the UCSF Graduate Endodontics Department. The purpose of the study is to evaluate and compare treatment outcomes between one-visit and two-visit root canal procedures. Participants who choose to continue in the study will be followed for a period of one year so that healing of the periapical abscess can be monitored. Follow-up appointments are scheduled at six months and twelve months after treatment completion, both of which are part of routine standard care. Clinical and radiographic findings documented in the Axium chart by the treating provider will be reviewed as part of the study analysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Classified as American Society of Anesthesiologists (ASA) Class I or II
  • presenting with radiographic evidence of apical periodontitis-defined as a Cone-Beam Computed Tomography Periapical Index (CBCTPAI) score of 3 or greater according to the Estrela classification

Exclusion criteria

  • Exclusion criteria included patients with uncontrolled chronic systemic conditions (e.g., diabetes, hypertension, chronic obstructive pulmonary disease), cardiovascular disease, renal or hepatic impairment, and autoimmune disorders
  • History of smoking
  • Periodontal disease with probing depths ≥ 3 mm.
  • Root fractures
  • Immature apices
  • Resorption
  • perforations
  • Inability to achieve rubber dam isolation
  • Lack of informed consent

Treatment and study plan

Calcium Hydroxide (CH)

Other

calcium hydroxide will be used as interim medication in the first visit and patients will return for the obturation in the second visit.

Control Group

Other

control group- no intervention

Primary outcomes

  1. Clinical and Radiographic Healing

    Time frame: 12 months

    The primary outcome was defined using a combined clinical and radiographic healing based on the Cone-Beam Computed Tomography Periapical Index (CBCT-PAI)

Secondary outcomes

  1. Volumetric Change in Periapical Lesion Size

    Time frame: 12 months

    The secondary outcome was defined as the change in lesion volume (mm³) between baseline and follow-up CBCT scans, serving as a quantitative metric of periapical healing

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Official study title

The Efficacy of Single-Visit and Two-Visit Endodontic Treatments for Necrotic Teeth With Apical Periodontitis

Acronym: RCT

Important dates

Study start
2021
Primary completion
2023
Study completion
2025
First posted
Jan 21, 2026
Registry last updated
Jan 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.