Skip to main content
OpenTrials
Completed

NCT Number: NCT01785641

Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in CAPD Patients

To compare the efficacy of single versus combined antibiotic therapy for bacterial peritonitis in CAPD patients.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Peritonitis Digestive System Diseases Infections Intraabdominal Infections Peritoneal Diseases

Age range

15 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chulalongkorn university

Bangkok, 10330, Thailand

About this study

To compare relapse and recurrent rate of peritonitis between single and combined antibiotic regimens for bacterial peritonitis in CAPD patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age >/= 18 years old
  • ESRD patients on continuous ambulatory peritoneal dialysis more than 4 weeks
  • presence of symptom or sign of peritonitis
  • presence of WBC >100cell/mm3 with PMN >50% in peritoneal dialysate or gram stain positive for gram positive or gram negative bacteria

Exclusion criteria

  • presence of polymicrobial organism, non-fermentative gram negative organism, fungus, mycobacteria in peritoneal fluid or culture-negative
  • peritonitis from the organisms that required combined antibiotic therapy according to ISPD guideline 2010
  • hospital-acquired peritonitis
  • presence of catheter-related infection
  • history of peritonitis within 4 weeks
  • currently taking antibiotic
  • allergic to the antibiotic that used in the study(penicillin or cephalosporin or quinolone or aminoglycoside)

Treatment and study plan

ceftazidime+ciprofloxacin

Drug

2 synergistic antibiotics: ceftazidime IP + ciprofloxacin po for gram negative bacterial peritonitis

Other names: combined antibiotic therapy

ceftazidime monotherapy

Drug

ceftazidime IP for gram negative bacterial peritonitis

Other names: monotherapy

cefazolin+gentamicin

Drug

cefazolin IP + gentamicin IP for gram positive bacterial peritonitis

Other names: combined antibiotic therapy

cefazolin monotherapy

Drug

cefazolin IP for gram positive bacterial peritonitis

Other names: monotherapy

Primary outcomes

  1. relapse or recurrent rate

    Time frame: within 4 weeks after peritonitis treatment

Sponsors and collaborators

Lead sponsor

Chulalongkorn University

Other

Registry information

Official study title

Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in Continuous Ambulatory Peritoneal Dialysis Patients

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Feb 7, 2013
Registry last updated
Feb 21, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.