Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure

Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity. This suggests that there may be genetic variants that make some patients susceptible to analgesic failure. Using blood samples from patients, the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in analgesic failure.

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Key information

Conditions

Pain, Postoperative Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Polymorphism, Single Nucleotide Postoperative Complications Signs and Symptoms Thoracic Surgery, Video-Assisted

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The second affiliated hospital of Zhejiang University

Hangzhou, Zhejiang, 310000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≤ 70 and Age ≥18
Selective operation lung section with video-assisted thoracic surgery (VATS)
III ≥ American Society of Anesthesiologists classification (ASA classification) ≥I
Patients informed and agreed to join the study

Exclusion criteria

Abnormal function of liver and kidney
Allergic- dependence history of alcohol, opioids and Local anesthetics
No noncompliance
Mental disease history，language communication disorder，cicatricial diathesis
Underweight or overweight（BMI<18 or >30)
Patients not suitable for clinical subjects for other reasons
Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24hours before the operation.
History of previous abnormal anaesthesia
Women during pregnancy or lactation

Treatment and study plan

Genetic analysis

Genetic

Collect 2ml intravenous blood from patients after anaesthesia.

Primary outcomes

Postoperative analgesic failure

Time frame: 8 a.m. at the first day after surgery.
Once patient experience at least one of the following situations:
- Bad patients sleep quality
- Require extra analgesic drug
- Low satisfaction with pain control
- Bolus times > 1 per hour

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Official study title

Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure After Single-port Video-Assisted Thoracoscopic Surgery

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Apr 16, 2019
Registry last updated: Apr 16, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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